Department of Pharmacy, Radboud university medical center, Nijmegen, The Netherlands
Center of Expertise in Mycology Radboudumc/CWZ and Radboud Institute of Health Science, Nijmegen, The Netherlands.
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00915-17. Print 2017 Sep.
Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.
联合伏立康唑和氟氯西林适用于同时患有侵袭性曲霉病和革兰阳性感染的患者群体（例如，患有慢性肉芽肿病或流感后肺部曲霉病的患者）。我们报告了伏立康唑和氟氯西林之间存在高度相关的相互作用，导致超过 50%的患者的伏立康唑血浆浓度低于治疗范围，如果不进行适当管理，这将构成严重威胁。
