在一例无幽门螺杆菌感染病史的病例中，胃增生性息肉与质子泵抑制剂的使用相关。
Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection.
作者信息
Miyamoto Shuichi, Kato Mototsugu, Matsuda Kana, Abiko Satoshi, Tsuda Momoko, Mizushima Takeshi, Yamamoto Keiko, Ono Shoko, Kudo Takahiko, Shimizu Yuichi, Hatanaka Kanako C, Tsunematsu Izumi, Sakamoto Naoya
机构信息
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan.
National Hospital Organization Hakodate Hospital, Japan.
出版信息
Intern Med. 2017;56(14):1825-1829. doi: 10.2169/internalmedicine.56.8040. Epub 2017 Jul 15.
Abstract
A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation. Thus, the administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection.
摘要
一名56岁的胃食管反流病（GERD）男性患者被转诊至我院。食管胃十二指肠镜检查（EGD）显示胃内无任何息肉样病变迹象，且该患者无幽门螺杆菌感染史。他因GERD每天服用一次奥美拉唑（20毫克）。在开始服用奥美拉唑1年后进行了EGD检查，此次发现了胃增生性息肉（GHP）。随着奥美拉唑治疗的持续，GHP的大小有所增加，但在停用奥美拉唑后其大小明显减小。因此，质子泵抑制剂的使用可能是独立于幽门螺杆菌感染之外导致GHP发生的一个危险因素。
相似文献
1
Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection.
Intern Med. 2017;56(14):1825-1829. doi: 10.2169/internalmedicine.56.8040. Epub 2017 Jul 15.
2
Adenocarcinoma arising in multiple hyperplastic polyps in a patient with Helicobacter pylori infection and hypergastrinemia during long-term proton pump inhibitor therapy.
Clin J Gastroenterol. 2017 Apr;10(2):128-136. doi: 10.1007/s12328-017-0714-7. Epub 2017 Feb 3.
3
Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.
J Clin Pharm Ther. 2015 Aug;40(4):368-75. doi: 10.1111/jcpt.12277. Epub 2015 Apr 20.
4
Haemorrhagic gastric hyperplastic polyps associated with long-term use of proton pump inhibitor in a case without Helicobacter pylori infection.
J Clin Pharm Ther. 2019 Jun;44(3):493. doi: 10.1111/jcpt.12819. Epub 2019 Feb 17.
5
[A Case of Cronkhite-Canada syndrome showing resolution with Helicobacter pylori eradication and omeprazole].
Korean J Gastroenterol. 2006 Jan;47(1):59-64.
6
Gastric corpus polyps associated with Proton Pump Inhibitors therapy.
J Coll Physicians Surg Pak. 2008 Mar;18(3):172-3.
7
Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan.
Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:102-6. doi: 10.1111/j.1365-2036.2004.01983.x.
8
9
The clinicopathological characteristics of gastric polyps and the relationship between fundic gland polyps, Helicobacter pylori infection, and proton pump inhibitors.
Ann Palliat Med. 2021 Feb;10(2):2108-2114. doi: 10.21037/apm-21-39.
10
Proton Pump Inhibitor Associated Multiple Gastric Hyperplastic Polyps With Uncontrollable Bleeding: A Case Report.
In Vivo. 2024 May-Jun;38(3):1465-1469. doi: 10.21873/invivo.13592.
引用本文的文献
1
Visibility Evaluation of Fundic Gland Polyp Associated With Proton Pump Inhibitor in Texture and Color Enhancement Imaging.
DEN Open. 2025 May 22;6(1):e70147. doi: 10.1002/deo2.70147. eCollection 2026 Apr.
2
Association between autoimmune gastritis and gastric polyps: Clinical characteristics and risk factors.
World J Gastrointest Oncol. 2025 Jan 15;17(1):92908. doi: 10.4251/wjgo.v17.i1.92908.
3
Proton Pump Inhibitor Associated Multiple Gastric Hyperplastic Polyps With Uncontrollable Bleeding: A Case Report.
In Vivo. 2024 May-Jun;38(3):1465-1469. doi: 10.21873/invivo.13592.
4
Severe Anemia from Multiple Gastric Hyperplastic Polyps in a Hemodialysis Patient after Long-term Use of a Proton-pump Inhibitor.
Intern Med. 2024;63(5):649-657. doi: 10.2169/internalmedicine.2091-23.
5
Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter Pylori-Uninfected Patient.
J Clin Med. 2023 Aug 22;12(17):5437. doi: 10.3390/jcm12175437.
6
Gastric Foveolar-type Adenocarcinoma with Raspberry-like Appearance in a Helicobacter pylori-uninfected Stomach: A Long-term Retrospective Follow-up of 16 Years.
Intern Med. 2023 Aug 1;62(15):2195-2200. doi: 10.2169/internalmedicine.0965-22. Epub 2022 Dec 7.
7
Occurrence of a Duodenal Polypoid Lesion During Long-Term Acid Suppression Therapy and Its Regression After Drug Discontinuation.
Case Rep Gastroenterol. 2021 Sep 2;15(3):779-784. doi: 10.1159/000518871. eCollection 2021 Sep-Dec.
8
Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non--Infected Stomach.
Case Rep Gastroenterol. 2021 Jun 21;15(2):539-544. doi: 10.1159/000514530. eCollection 2021 May-Aug.
9
Gastritis, Gastric Polyps and Gastric Cancer.
Int J Mol Sci. 2021 Jun 18;22(12):6548. doi: 10.3390/ijms22126548.
10
Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis.
Case Rep Gastroenterol. 2021 Feb 18;15(1):202-209. doi: 10.1159/000511885. eCollection 2021 Jan-Apr.
本文引用的文献
1
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
Biochem Biophys Res Commun. 2016 Jun 17;475(1):119-24. doi: 10.1016/j.bbrc.2016.05.052. Epub 2016 May 11.
2
Medical and non-medical predictors of initiating long-term use of proton pump inhibitors: a nationwide cohort study of first-time users during a 10-year period.
Aliment Pharmacol Ther. 2016 Jul;44(1):78-87. doi: 10.1111/apt.13649. Epub 2016 May 3.
3
Effect of Helicobacter pylori infection and its eradication on the fate of gastric polyps.
Eur J Gastroenterol Hepatol. 2016 Apr;28(4):449-54. doi: 10.1097/MEG.0000000000000553.
4
Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study.
World J Gastrointest Endosc. 2015 Aug 10;7(10):995-1002. doi: 10.4253/wjge.v7.i10.995.
5
Ménétrier Mimicker Complicating Ulcerative Colitis: Proton-Pump Inhibitor-Induced Hyperplastic Polyps.
J Pediatr. 2015 Sep;167(3):776.e1. doi: 10.1016/j.jpeds.2015.06.030. Epub 2015 Jul 21.
6
Neoplasms arising in large gastric hyperplastic polyps: endoscopic and pathologic features.
Gastrointest Endosc. 2014 Dec;80(6):1005-13.e2. doi: 10.1016/j.gie.2014.04.020. Epub 2014 Jun 11.
7
Helicobacter gastritis induces changes in the oxyntic mucosa indistinguishable from the effects of proton pump inhibitors.
Hum Pathol. 2013 Dec;44(12):2706-10. doi: 10.1016/j.humpath.2013.07.015. Epub 2013 Sep 24.
8
[Gastric hyperplastic polyps and H. pylori infection, their relationship and effects of eradication therapy].
Nihon Rinsho. 2013 Aug;71(8):1449-52.
9
High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis.
Dig Dis Sci. 2013 Mar;58(3):634-40. doi: 10.1007/s10620-012-2427-6. Epub 2012 Oct 5.
10
A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy.
Ger Med Sci. 2010 Sep 2;8:Doc19. doi: 10.3205/000108.
Zotero 插件