Gao Wei, Huang Yushuang, Lu Shuming, Li Chunyan
Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
The Second Department of Hepatopathy, the Sixth People's Hospital of Dalian, Dalian, China.
Ann Palliat Med. 2021 Feb;10(2):2108-2114. doi: 10.21037/apm-21-39.
To explore the clinical characteristics of different types of gastric polyps and the relationship between fundic gland polyps, Helicobacter pylori (HP) infection, and proton pump inhibitor (PPI) use.
The clinical data of 186 patients diagnosed with gastric polyps under endoscopy were selected for retrospective analysis, and the clinical data, gastroscopy, polyp histopathology, HP infection, and PPI usage of all subjects were analyzed.
Among the 186 patients with gastric polyps, there were significantly more women (131 cases) than men (55 cases), with a ratio of 2.38:1. PPIs were used in 78% of cases for more than 5 years. The pathological types of patients with gastric polyps in this study were fundic gland polyps, hyperplastic polyps, inflammatory fibrous polyps, and adenomatous polyps. Fundic gland polyps were mainly located in the fundus and gastric body, while hyperplastic polyps were mostly located in the gastric body (P<0.05). The positive rate of HP infection in patients with fundic gland polyps was significantly lower than that in patients with other types of polyps (P<0.05). In patients with long-term use of PPIs, the incidence of fundic gland polyps increased significantly (P<0.05).
There were significant differences among the different types of gastric polyps in terms of polyp position, shape, and size. The positive rate of HP infection in patients with fundic gland polyps was low. Long-term use of PPIs (>5 years) increased the incidence of fundic gland polyps to some extent. The mechanisms underlying the relationship between gastric polyps, HP infection, and the use of PPIs remain to be further studied.
探讨不同类型胃息肉的临床特征以及胃底腺息肉、幽门螺杆菌（HP）感染与质子泵抑制剂（PPI）使用之间的关系。
选取186例经内镜诊断为胃息肉的患者的临床资料进行回顾性分析，对所有受试者的临床资料、胃镜检查、息肉组织病理学、HP感染及PPI使用情况进行分析。
186例胃息肉患者中，女性（131例）明显多于男性（55例），比例为2.38∶1。78%的病例使用PPI超过5年。本研究中胃息肉患者的病理类型为胃底腺息肉、增生性息肉、炎性纤维息肉和腺瘤性息肉。胃底腺息肉主要位于胃底和胃体，而增生性息肉大多位于胃体（P<0.05）。胃底腺息肉患者的HP感染阳性率明显低于其他类型息肉患者（P<0.05）。长期使用PPI的患者中，胃底腺息肉的发生率显著增加（P<0.05）。
不同类型胃息肉在息肉位置、形态和大小方面存在显著差异。胃底腺息肉患者的HP感染阳性率较低。长期使用PPI（>5年）在一定程度上增加了胃底腺息肉的发生率。胃息肉、HP感染与PPI使用之间关系的潜在机制仍有待进一步研究。
