一例使用β-1a干扰素治疗的多发性硬化症患者暴发性肝炎尸检病例
An Autopsy Case of Fulminant Hepatitis in a Patient with Multiple Sclerosis Treated by Interferon-Beta-1a.
作者信息
Yamazaki Yuichi, Suzuki Aya, Hirayanagi Kimitoshi, Tsukagoshi Yusuke, Uehara Ryota, Horiguchi Kazuhiko, Ohyama Tatsuya, Tomaru Takuya, Horiguchi Norio, Nobusawa Sumihito, Ikota Hayato, Sato Ken, Kakizaki Satoru, Kusano Motoyasu, Ikeda Yoshio, Yokoo Hideaki, Yamada Masanobu
机构信息
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan.
Department of Pathology, Gunma University Hospital, Japan.
出版信息
Intern Med. 2017;56(14):1897-1901. doi: 10.2169/internalmedicine.56.7980. Epub 2017 Jul 15.
A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH based on hepatic coma, severe liver injury and liver failure, and she received plasma exchange and continuous hemodiafiltration therapy. On hospital day 6, she died from liver failure despite intensive care. An autopsy revealed histological findings consistent with FH. Physicians should monitor the hepatic function of MS patients receiving IFN-beta-1a treatment, as serious events can occur in rare cases.
一名44岁接受β-1a干扰素治疗的多发性硬化症（MS）女性因严重黄疸和肝损伤入住当地医院。因怀疑是暴发性肝炎（FH），她被转至我们的大学医院。基于肝昏迷、严重肝损伤和肝衰竭，她被诊断为急性型FH，并接受了血浆置换和持续血液透析滤过治疗。住院第6天，尽管进行了重症监护，她仍死于肝衰竭。尸检显示组织学结果与FH一致。医生应监测接受β-1a干扰素治疗的MS患者的肝功能，因为在罕见情况下可能会发生严重事件。
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