Sun Wei, Yang Yudan, Yu Hongmei, Wang Luowei, Pan Su
Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun Jilin, China.
China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.
Dose Response. 2017 Jun 30;15(2):1559325817711511. doi: 10.1177/1559325817711511. eCollection 2017 Apr-Jun.
The phenomena of hypergravity and microwave radiation are widespread, which cause more and more concern for the hazards to human health. The aim of this study was to investigate the synergistic effect of microwave radiation and hypergravity on rats and observe the protective effect of Rana sylvatica Le conte oil.
Rats were exposed to microwave radiation and hypergravity, and the rat weight, the climbing pole height, serum enzyme activities, blood urea nitrogen concentration, and total antioxidant capacity were detected.
The climbing pole height, the activities of choline acetyl transferase and cholinesterase, and the total antioxidant capacity decreased, whereas the activities of alanine aminotransferase, aspartate aminotransferase, areatine kinase, isocitric dehydrogenase, hydroxybutyrate dehydrogenase, and the blood urea nitrogen concentration increased in the hypergravity irradiation group as compared with the others.
These results imply that the motion and nervous system of rats might be affected critically by the synergistic effect of microwave radiation and hypergravity, and it causes damage to most rat organs, such as the bone, skeletal muscle, liver, heart, and kidney, and the antioxidant effect is also damaged, while the injury resulted from it could be protected by Rana sylvatica Le conte oil.
超重和微波辐射现象广泛存在，其对人类健康的危害日益受到关注。本研究旨在探讨微波辐射与超重对大鼠的协同作用，并观察林蛙油的保护作用。
将大鼠暴露于微波辐射和超重环境中，检测大鼠体重、爬杆高度、血清酶活性、血尿素氮浓度及总抗氧化能力。
与其他组相比，超重辐射组大鼠的爬杆高度、胆碱乙酰转移酶和胆碱酯酶活性以及总抗氧化能力降低，而丙氨酸氨基转移酶、天冬氨酸氨基转移酶、肌酸激酶、异柠檬酸脱氢酶、羟丁酸脱氢酶活性及血尿素氮浓度升高。
这些结果表明，微波辐射与超重的协同作用可能严重影响大鼠的运动和神经系统，对大鼠的骨骼、骨骼肌、肝脏、心脏和肾脏等多数器官造成损伤，同时抗氧化作用也受到损害，而林蛙油可对由此导致的损伤起到保护作用。
