三种大流行病的碰撞：撒哈拉以南国家博茨瓦纳宫颈癌、艾滋病毒感染和既往结核病的共存
Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana.
作者信息
Zetola Nicola M, Grover Surbhi, Modongo Chawangwa, Chiyapo Sebathu P, Nsingo-Bvochora Memory, Narasimhamurthy Mohan, Lin Lilie L, Jarvis Joseph, Shin Sanghyuk S, Robertson Erle
机构信息
, , , and , University of Pennsylvania, Philadelphia, PA; , , and , University of Botswana; , Botswana-University of Pennsylvania Partnership; , Princess Marina Hospital; , Gaborone Private Hospital, Gaborone, Botswana; , London School of Hygiene and Tropical Medicine, London, United Kingdom; and , University of California-Los Angeles, Los Angeles, CA.
出版信息
J Glob Oncol. 2016 Jan 13;2(1):47-50. doi: 10.1200/JGO.2015.001701. eCollection 2016 Feb.
Cervical cancer is the leading cause of cancer-related mortality in the developing world, where HIV and (TB) infection are also endemic. HIV infection is independently associated with increased morbidity and mortality among women with cervical cancer. TB is believed to increase the risk of malignancies and could cause chronic inflammation in the gynecologic tract. However, the relationship between cervical cancer and TB in settings hyperendemic for HIV is unknown. We found that 18 (10%) of a cohort of 180 women with cervical cancer in Botswana had a history of TB disease. Age and HIV infection were also associated with a history of TB disease. Our data show that prior TB disease is highly prevalent among patients with cervical cancer infected with HIV. The coexistence of cervical cancer, HIV infection, and prior TB infection might be higher than expected in the general population. Prospective studies are needed to better determine the impact of the collision of these three world health epidemics.
宫颈癌是发展中世界癌症相关死亡的主要原因，在这些地区，艾滋病毒和结核病感染也很流行。艾滋病毒感染与宫颈癌女性患者发病率和死亡率增加独立相关。结核病被认为会增加患恶性肿瘤的风险，并可能导致生殖道慢性炎症。然而，在艾滋病毒高度流行的地区，宫颈癌与结核病之间的关系尚不清楚。我们发现，在博茨瓦纳的180名宫颈癌女性队列中，有18人（10%）有结核病病史。年龄和艾滋病毒感染也与结核病病史有关。我们的数据表明，既往结核病在感染艾滋病毒的宫颈癌患者中非常普遍。宫颈癌、艾滋病毒感染和既往结核病感染同时存在的情况在普通人群中可能比预期的更高。需要进行前瞻性研究，以更好地确定这三种全球健康流行病碰撞所产生的影响。
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