Okawa K K
Angiology. 1986 Mar;37(3 Pt 2):233-8. doi: 10.1177/000331978603700315.
This multicenter study, conducted to determine the antihypertensive efficacy of bevantolol at different fixed doses compared with placebo was carried out at four separate institutions using a common protocol. One hundred thirty-nine patients with mild to moderate essential hypertension were enrolled. At doses of 200 to 400 mg/day bevantolol was clearly effective in lowering diastolic blood pressure and in maintaining this effect over the eight weeks of this double-blind study. Twice a day dosing is indicated since efficacy was evident 12 hours post-dosing. Bevantolol was well tolerated.
这项多中心研究在四个不同机构按照通用方案进行，旨在确定与安慰剂相比，不同固定剂量的贝凡洛尔的降压疗效。139例轻度至中度原发性高血压患者入组。在本双盲研究的八周期间，每天服用200至400毫克贝凡洛尔可显著降低舒张压并维持该效果。由于给药12小时后疗效明显，故建议每日给药两次。贝凡洛尔耐受性良好。
