Weiner L, Frithz G
Eur J Clin Pharmacol. 1986;29(5):517-21. doi: 10.1007/BF00635886.
Bisoprolol is a new beta 1-selective beta-blocking agent with a plasma half-time of 10-12 h and without partial agonist properties. Forty-eight patients with essential hypertension were randomly treated with 5, 10, or 20 mg bisoprolol given once daily for 8 weeks. All measurements were made 24 hours after the last dose. Bisoprolol had antihypertensive and beta-blocking properties both at rest and during exercise. The 20 mg dosage regimen was more effective than that of 5 mg and 10 mg. The drug was well tolerated and all the 48 patients completed the trial.
比索洛尔是一种新型的β1选择性β受体阻滞剂，血浆半衰期为10 - 12小时，无部分激动剂特性。48例原发性高血压患者被随机分为三组，分别每日一次服用5毫克、10毫克或20毫克比索洛尔，疗程8周。所有测量均在末次给药24小时后进行。比索洛尔在静息和运动时均具有降压及β受体阻滞作用。20毫克剂量方案比5毫克和10毫克剂量方案更有效。该药物耐受性良好，48例患者均完成了试验。
