School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, People's Republic of China.
Arch Toxicol. 2017 Sep;91(9):3039-3049. doi: 10.1007/s00204-017-2024-8. Epub 2017 Jul 17.
Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.
药物性肝损伤一直是药物开发领域当前研究的重点，也是药物开发过程中失败和撤市的主要原因之一。许多公共数据库中系统地记录了药物性肝损伤，这些数据库已成为该领域的宝贵资源。在本研究中，我们概述了这些数据库，包括肝损伤特异性数据库 LiverTox、LTKB、Open TG-GATEs、LTMap 和 Hepatox，以及一般数据库 T3DB、DrugBank、DITOP、DART、CTD 和 HSDB。详细总结和讨论了这些数据库的特点和局限性。除了功能强大之外，我们认为还可以通过以下几种方式改进这些数据库：提供涉及肝毒性的分子靶点的数据，纳入药物相互作用引起的肝损伤信息，并定期更新数据。
