Vanacker Hélène, Vetters Jessica, Moudombi Lyvia, Caux Christophe, Janssens Sophie, Michallet Marie-Cécile
Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, 69008, France.
Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium and Department of Internal Medicine, Ghent University, Ghent, Belgium.
Trends Cancer. 2017 Jul;3(7):491-505. doi: 10.1016/j.trecan.2017.05.005. Epub 2017 Jul 6.
Disruption of endoplasmic reticulum (ER) homeostasis results in ER stress and activation of the unfolded protein response (UPR). This response alleviates cell stress, and is activated in both tumor cells and tumor infiltrating immune cells. The UPR plays a dual function in cancer biology, acting as a barrier to tumorigenesis at the premalignant stage, while fostering cancer maintenance in established tumors. In infiltrating immune cells, the UPR has been involved in both immunosurveillance and immunosuppressive functions. This review aims to decipher the role of the UPR at different stages of tumorigenesis and how the UPR shapes the balance between immunosurveillance and immune escape. This knowledge may improve existing UPR-targeted therapies and the design of novel strategies for cancer treatment.
内质网（ER）稳态的破坏会导致内质网应激和未折叠蛋白反应（UPR）的激活。这种反应可减轻细胞应激，在肿瘤细胞和肿瘤浸润免疫细胞中均被激活。UPR在癌症生物学中发挥双重作用，在癌前阶段作为肿瘤发生的屏障，而在已形成的肿瘤中促进癌症维持。在浸润性免疫细胞中，UPR参与了免疫监视和免疫抑制功能。本综述旨在阐明UPR在肿瘤发生不同阶段的作用，以及UPR如何塑造免疫监视和免疫逃逸之间的平衡。这些知识可能会改善现有的针对UPR的疗法，并为癌症治疗设计新的策略。
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