Laboratory of Chemical Biology and Signal Transduction, Rockefeller University, New York, NY 10065, USA.
Tri-Institutional PhD Program in Chemical Biology, New York, NY 10065, USA.
Sci Signal. 2024 Sep 17;17(854):eadp3967. doi: 10.1126/scisignal.adp3967.
In contrast with sun exposure-induced melanoma, rarer melanocytic tumors and neoplasms with low mutational burden present opportunities to study isolated signaling mechanisms. These include uveal melanoma and blue nevi, which are often driven by mutations within the G protein-coupled signaling cascade downstream of cysteinyl leukotriene receptor 2. Here, we review how the same mutations within this pathway drive the growth of melanocytes in one tissue but can inhibit the growth of those in another, exemplifying the role of the tissue environment in the delicate balance between uncontrolled cell growth and senescence.
与阳光照射引起的黑色素瘤相反，罕见的黑色素细胞肿瘤和突变负担较低的肿瘤为研究孤立的信号机制提供了机会。这些肿瘤包括葡萄膜黑色素瘤和蓝色痣，它们通常由半胱氨酰白三烯受体 2 下游的 G 蛋白偶联信号级联中的突变驱动。在这里，我们回顾了该途径中的相同突变如何驱动一种组织中黑素细胞的生长，但又可以抑制另一种组织中黑素细胞的生长，这说明了组织环境在失控的细胞生长和衰老之间的微妙平衡中的作用。
