癌症——克隆体的叛乱

Cancer - An Insurgency of Clones.

作者信息

Gisselsson David, Egnell Robert

机构信息

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden; Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Pathology, Skåne University and Regional Laboratories, Lund, Sweden.

Department of Security, Strategy and Leadership, Swedish Defence University, Stockholm, Sweden.

出版信息

Trends Cancer. 2017 Feb;3(2):73-75. doi: 10.1016/j.trecan.2016.11.010. Epub 2016 Dec 23.

DOI:10.1016/j.trecan.2016.11.010

PMID:28718446

Abstract

Oncological therapy resembles a military force that eliminates the central power of a country (dominant clone of a cancer) to create a vacuum where insurgents (subclones) thrive and instigate rebellion (relapse). We suggest that military counterinsurgency doctrine can inspire a discussion of cancer that uniquely embraces both cancer cell evolution and tumour microenvironment.

摘要

肿瘤治疗类似于一支军事力量，它消灭一个国家的中央政权（癌症的优势克隆）以制造出一个真空地带，在这个地带叛乱分子（亚克隆）得以繁荣并煽动叛乱（复发）。我们认为军事反叛乱理论能够激发对癌症的讨论，这种讨论独特地涵盖了癌细胞进化和肿瘤微环境。