Santos Anderson R, Benghi Thalita Gilda S, Nepel Angelita, Marques Francisco A, Lobão Adriana Q, Duarte Marta Cristina T, Ruiz Ana Lúcia T G, Carvalho João E, Maia Beatriz H L N S
Departament of Chemistry, Centro Politécnico, Federal University of Paraná, Curitiba, Paraná, Brazil.
Departament of General Biology, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Chem Biodivers. 2017 Oct;14(10). doi: 10.1002/cbdv.201700097. Epub 2017 Sep 13.
The essential oils (EOs) extracted from four species of the genus Guatteria, G. australis, G. ferruginea, G. latifolia, and G. sellowiana were analyzed. A total of 24, 22, 25, and 19 constituents of the oils from four species, respectively, were identified by GC/MS. These oils showed qualitative and quantitative differences. All the oils contained the oxygenated sesquiterpenes spathulenol (11.04 - 40.29%) and caryophyllene oxide (7.74 - 40.13%) as predominant constituents. Evaluation of antiproliferative activity of the EOs showed strong selectivity (1.1 - 4.1 μg/ml) against the tumor cell line OVCAR-03 (ovarian cancer), i.e., more active than the positive control doxorubicin (11.7 μg/ml). All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 0.062 - 0.25 mg/ml) against strains of Rhodococcus equi.
对从番荔枝属的四种植物，即南方番荔枝、锈色番荔枝、阔叶番荔枝和塞尔维番荔枝中提取的精油进行了分析。通过气相色谱/质谱联用仪分别鉴定出这四种植物精油中的24种、22种、25种和19种成分。这些精油在定性和定量方面存在差异。所有精油均含有氧化倍半萜spathulenol（含量为11.04 - 40.29%）和石竹烯氧化物（含量为7.74 - 40.13%）作为主要成分。对这些精油的抗增殖活性评估显示，它们对肿瘤细胞系OVCAR - 03（卵巢癌）具有很强的选择性（1.1 - 4.1微克/毫升），即比阳性对照阿霉素（11.7微克/毫升）更具活性。所有精油对马红球菌菌株均表现出很强的抗菌活性（最低抑菌浓度为0.062 - 0.25毫克/毫升）。
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