Programa de Pós-Graduação em Química, Universidade Federal do Pará, Rua Augusto Corrêa S/N, Guamá, Belém 66075-900, PA, Brazil.
Faculdade de Química, Universidade Federal do Pará, Rua Augusto Corrêa S/N, Guamá, Belém 66075-900, PA, Brazil.
Int J Mol Sci. 2021 Nov 9;22(22):12140. doi: 10.3390/ijms222212140.
The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas-for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as L. and A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, ()-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.
本研究对 2011 年至 2021 年间在巴西采集的番荔枝科植物精油的化学成分和生物效应进行了系统综述。番荔枝科是巴西最重要的植物科之一，因为一些物种在市场上具有经济价值，是当地和国际水果。此外，这些物种在多个领域有有用的应用，例如，作为化妆品和香水的原料以及药用植物。在民间医学中，如 L. 和 A. St.-Hil.等物种被用于治疗风湿和疟疾等疾病。番荔枝科植物是精油的重要来源，富含属于单萜和倍半萜类的化合物；其中，α-蒎烯、β-蒎烯、柠檬烯、( )-石竹烯、双环倍半萜、石竹烯氧化物、大根香叶烯 D、蛇麻烯醇和 β-榄香烯最为丰富。巴西番荔枝科植物精油具有抗菌、抗炎、抗利什曼原虫、抗氧化、抗增殖、细胞毒性、杀幼虫、杀锥虫和抗疟活性，此前的研究已经对其进行了描述，其中关于抗增殖或细胞毒性活性的研究最多。在一些研究中，观察到这些精油的生物活性优于市场上可用药物的活性，如 (Aubl.) R. A. Howard. 物种的精油，其杀锥虫作用比参考药物苯并硝唑强 34 倍。
