Brudzynski S M, Houghton P E, Brownlee R D, Mogenson G J
Brain Res Bull. 1986 Mar;16(3):377-81. doi: 10.1016/0361-9230(86)90059-6.
The locomotor activity of freely-moving rats was increased substantially by injections of L-sodium glutamate or of picrotoxin, a GABA antagonist, into the region of the tegmental pedunculopontine nucleus. The onset of hyper-motility was more rapid with L-glutamate than with picrotoxin and the duration shorter. Locomotor activity from injecting amphetamine unilaterally into the nucleus accumbens was reduced by injections of GABA into the ipsilateral pedunculopontine nucleus. These observations provide additional evidence implicating neurons of the MLR and possibly GABA synaptic inputs to these neurons in locomotor activity and suggest that they may mediate indirect inputs from the nucleus accumbens.
向被自由移动大鼠的被盖脚桥核区域注射L - 谷氨酸钠或γ-氨基丁酸（GABA）拮抗剂印防己毒素，可显著增加其运动活性。L - 谷氨酸诱发的运动亢进发作比印防己毒素更快，持续时间更短。向伏隔核单侧注射苯丙胺后，向同侧脚桥核注射GABA可降低运动活性。这些观察结果提供了更多证据，表明中脑网状结构（MLR）的神经元以及可能是这些神经元的GABA突触输入与运动活性有关，并表明它们可能介导来自伏隔核的间接输入。
