Akomolafe Seun F, Oboh Ganiyu, Oyeleye Sunday I, Olasehinde Tosin A
1 Ekiti State University, Ado Ekiti, Nigeria.
2 Federal University of Technology, Akure, Nigeria.
J Evid Based Complementary Altern Med. 2017 Oct;22(4):919-925. doi: 10.1177/2156587217718979. Epub 2017 Jul 18.
Tetracarpidium conophorum leaves are used in traditional medicine for the treatment of male infertility, without considering its toxicity and side effects. In this study, we investigated the effects of T conophorum leaves on some biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, bilirubin, albumin, creatinine, and uric acid. Histology of the liver and kidney were also assessed. The result revealed that the alanine aminotransferase and aspartate aminotransferase levels of the control group were not significantly different from the experimental groups. There was no significant difference in the albumin and bilirubin levels of the control and experimental groups. Similarly, the uric acid and creatinine levels of the experimental rats were not significantly different from the control. The examination of liver and kidney sections did not show any morphological changes and inflammatory cell infiltrations. These findings suggest that the leaves did not induce any pathological changes at the doses tested.
四棱豆叶在传统医学中用于治疗男性不育症，而未考虑其毒性和副作用。在本研究中，我们调查了四棱豆叶对一些生化参数的影响，如丙氨酸转氨酶、天冬氨酸转氨酶、胆红素、白蛋白、肌酐和尿酸。还评估了肝脏和肾脏的组织学。结果显示，对照组的丙氨酸转氨酶和天冬氨酸转氨酶水平与实验组无显著差异。对照组和实验组的白蛋白和胆红素水平无显著差异。同样，实验大鼠的尿酸和肌酐水平与对照组无显著差异。肝脏和肾脏切片检查未显示任何形态学变化和炎性细胞浸润。这些发现表明，在所测试的剂量下，四棱豆叶未引起任何病理变化。
