Balaña-Fouce R, Pulido T G, Escudero D O, Sanz-Sanchez F
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(2):419-21. doi: 10.1016/0742-8413(86)90146-5.
Two phenylated compounds of methylglyoxal bis(guanylhydrazone), potentially inhibitors of diamine oxidase activity, have been synthesized: phenylglyoxal bis(guanylhydrazone) and diphenylglyoxal bis(guanylhydrazone). Their inhibitory capacity was tested: while PGBG was able to reduce the enzyme activity by 50% at 1.3 microM, DPGBG was only able to reduce diamine oxidase activity by less than 2% at a concentration 1000-fold higher. The inhibition of PGBG was non-competitive and the Ki calculated by a Dixon plot was estimated as 1.7 microM.
