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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

San-Martín Núñez B, Alunda J M, Balaña-Fouce R, Ordóñez Escudero D

Departamento de Toxicología y Farmacología, Facultad de Veterinaria Universidad Complutense de Madrid, Spain.

Comp Biochem Physiol B. 1987;87(4):863-6. doi: 10.1016/0305-0491(87)90403-2.

Activity of S-adenosylmethionine decarboxylase, one of the rate-limiting enzymes of polyamine biosynthesis, was determined in oocysts of Eimeria stiedai, a coccidian parasite of the rabbit. 2. Several properties of the enzyme were compared to the mammalian enzyme. It showed considerably less substrate affinity than the analog enzyme from the rabbit. 3. The E. stiedai enzyme showed a low sensitivity to methylglyoxal bis(guanylhydrazone), a frequently used inhibitor of the enzyme in mammals, and two phenylated derivatives. 4. Results with the inhibitors are discussed in view of their potential use in chemotherapy.

测定了艾美耳球虫（兔的一种球虫寄生虫）斯氏艾美耳球虫卵囊中多胺生物合成的限速酶之一S-腺苷甲硫氨酸脱羧酶的活性。2. 将该酶的几个特性与哺乳动物的酶进行了比较。它显示出的底物亲和力比来自兔的类似酶低得多。3. 斯氏艾美耳球虫的酶对甲基乙二醛双（脒腙）（一种在哺乳动物中常用的该酶抑制剂）和两种苯基化衍生物的敏感性较低。4. 鉴于抑制剂在化疗中的潜在用途，对抑制剂的结果进行了讨论。

San-Martín Núñez B, Alunda J M, Balaña-Fouce R, Ordóñez Escudero D

Departamento de Toxicología y Farmacología, Facultad de Veterinaria Universidad Complutense de Madrid, Spain.

Comp Biochem Physiol B. 1987;87(4):863-6. doi: 10.1016/0305-0491(87)90403-2.

Activity of S-adenosylmethionine decarboxylase, one of the rate-limiting enzymes of polyamine biosynthesis, was determined in oocysts of Eimeria stiedai, a coccidian parasite of the rabbit. 2. Several properties of the enzyme were compared to the mammalian enzyme. It showed considerably less substrate affinity than the analog enzyme from the rabbit. 3. The E. stiedai enzyme showed a low sensitivity to methylglyoxal bis(guanylhydrazone), a frequently used inhibitor of the enzyme in mammals, and two phenylated derivatives. 4. Results with the inhibitors are discussed in view of their potential use in chemotherapy.

测定了艾美耳球虫（兔的一种球虫寄生虫）斯氏艾美耳球虫卵囊中多胺生物合成的限速酶之一S-腺苷甲硫氨酸脱羧酶的活性。2. 将该酶的几个特性与哺乳动物的酶进行了比较。它显示出的底物亲和力比来自兔的类似酶低得多。3. 斯氏艾美耳球虫的酶对甲基乙二醛双（脒腙）（一种在哺乳动物中常用的该酶抑制剂）和两种苯基化衍生物的敏感性较低。4. 鉴于抑制剂在化疗中的潜在用途，对抑制剂的结果进行了讨论。