Fujii Masayuki, Sato Toshiro
Department of Gastroenterology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Genome Med. 2017 Jul 18;9(1):66. doi: 10.1186/s13073-017-0460-y.
Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5 intestinal stem cells, providing insights into their roles in homeostasis and cancer.
绒毛和隐窝。隐窝中含有表达Lgr5的干细胞，因此一直是研究组织干细胞功能的典型模型。类器官技术和分析方法的最新进展使得对Lgr5肠干细胞进行精确表征成为可能，这为深入了解它们在体内平衡和癌症中的作用提供了线索。
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