界定Lgr5干细胞在结直肠癌中的作用：从基础研究到临床应用
Defining the role of Lgr5 stem cells in colorectal cancer: from basic research to clinical applications.
作者信息
Fujii Masayuki, Sato Toshiro
机构信息
Department of Gastroenterology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
出版信息
Genome Med. 2017 Jul 18;9(1):66. doi: 10.1186/s13073-017-0460-y.
Abstract
Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5 intestinal stem cells, providing insights into their roles in homeostasis and cancer.
摘要
肠上皮由两个不同的部分构成
绒毛和隐窝。隐窝中含有表达Lgr5的干细胞，因此一直是研究组织干细胞功能的典型模型。类器官技术和分析方法的最新进展使得对Lgr5肠干细胞进行精确表征成为可能，这为深入了解它们在体内平衡和癌症中的作用提供了线索。
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