抗流感药物静脉注射帕拉米韦治疗合并基础疾病老年患者流感病毒感染的安全性和有效性

Safety and efficacy of anti-influenza drugs, intravenous peramivir against influenza virus infection in elderly patients with underlying disease.

作者信息

Takamatsu Kazufumi, Marumo Satoshi, Fukui Motonari, Hata Atsuko

机构信息

Department of Respiratory Medicine, Tazuke Kofukai Medical Research Institute Kitano Hospital, Japan.

Department of Respiratory Medicine, Tazuke Kofukai Medical Research Institute Kitano Hospital, Japan; Department of Infectious Diseases, Tazuke Kofukai Medical Research Institute Kitano Hospital, Japan.

出版信息

J Microbiol Immunol Infect. 2017 Aug;50(4):541-544. doi: 10.1016/j.jmii.2016.11.006. Epub 2017 Jun 26.

DOI:10.1016/j.jmii.2016.11.006

PMID:28720319

Abstract

We retrospectively analyzed data of 38 elderly patients, each with an underlying disease, to evaluate peramivir safety and efficacy. Six patients (15.8%) experienced adverse events, all tolerated. Median time from administration until the return to normal temperatures was 31.5 h (95% CI: 22.4-40.6). Results confirm intravenous peramivir's usefulness.

摘要

我们回顾性分析了38例患有基础疾病的老年患者的数据，以评估帕拉米韦的安全性和有效性。6例患者（15.8%）出现不良事件，均能耐受。从给药到体温恢复正常的中位时间为31.5小时（95%置信区间：22.4 - 40.6）。结果证实了静脉注射帕拉米韦的有效性。