Nazario M
Drug Intell Clin Pharm. 1986 May;20(5):342-8. doi: 10.1177/106002808602000502.
Cimetidine is one of the most frequently prescribed drugs with a known potential to interfere with the metabolic disposition of numerous other medications. Some of these drug interactions may be hazardous to patients. The hepatic and renal mechanisms of drug interactions with cimetidine are discussed in this article. The interactive processes include inhibition of hepatic microsomal enzyme activity, reduction of liver blood flow, and competition for renal tubular secretory sites. The clinical significance and proposed mechanisms of interaction for individual drugs are also presented.
西咪替丁是最常被处方的药物之一，已知它有干扰许多其他药物代谢处置的潜在可能。其中一些药物相互作用可能对患者有害。本文讨论了与西咪替丁发生药物相互作用的肝脏和肾脏机制。相互作用过程包括抑制肝微粒体酶活性、减少肝血流量以及竞争肾小管分泌位点。还介绍了个别药物相互作用的临床意义和推测机制。
