Argyri E, Tsimplaki E, Marketos C, Politis G, Panotopoulou E
Virology Department, Saint Savvas General Anticancer Hospital, Athens, Greece.
Pulmonary Department, Saint Savvas General Anticancer Hospital, Athens, Greece.
Papillomavirus Res. 2017 Jun;3:7-10. doi: 10.1016/j.pvr.2016.12.002. Epub 2016 Dec 7.
Lung cancer is the leading cancer worldwide among men and women with morbidity reaching 1.6 million. Human Papillomavirus is the causal factor of cervical cancer while its association with others is still under investigation. The purpose of our study is to examine the presence of HPV DNA as well as high-risk E6/E7 mRNA in patients with lung cancer. Lung tissues were collected during bronchoscopy and tested for HPV DNA and E6/E7 mRNA. 67 lung tissue samples were analysed. The age range was 49-85 years old (y.o) with a mean age of 67.6 y.o. 9 patients were female and 58 were male. The study included 12 Small Cell Lung Cancers (SCLC) and 55 Non Small Cell Lung Cancer (NSCLC). HPV DNA was detected in 3.0% (2/67) of lung cancer cases, while no E6/E7 mRNA of five high-risk HPV types was found in tissue samples examined. The two positive patients had no prior history of an HPV related disease. Using the mRNA test as a gold standard for the association of HPV with malignant transformation, the present results showed no association of HPV status with lung cancer. Further investigation of more lung cancer tissues is required to reach safe conclusions.
肺癌是全球男性和女性中最主要的癌症，发病率达160万。人乳头瘤病毒是宫颈癌的致病因素，但其与其他癌症的关联仍在研究中。我们研究的目的是检测肺癌患者中HPV DNA以及高危E6/E7 mRNA的存在情况。在支气管镜检查期间收集肺组织，并检测HPV DNA和E6/E7 mRNA。分析了67份肺组织样本。年龄范围为49至85岁，平均年龄为67.6岁。9例为女性，58例为男性。该研究包括12例小细胞肺癌（SCLC）和55例非小细胞肺癌（NSCLC）。在3.0%（2/67）的肺癌病例中检测到HPV DNA，而在所检查的组织样本中未发现五种高危HPV类型的E6/E7 mRNA。这两名阳性患者既往无HPV相关疾病史。以mRNA检测作为HPV与恶性转化关联的金标准，目前结果显示HPV状态与肺癌无关联。需要对更多肺癌组织进行进一步研究才能得出可靠结论。
