在 3D 胶原网络中肌成纤维细胞分化过程中模拟旁分泌 TGFβ1 信号。
Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks.
机构信息
Universität Leipzig, Institute of Biochemistry, Johannisallee 21/23, 04103, Leipzig, Germany.
Universitätsklinikum Leipzig, Department of Dermatology, Venereology and Allergology, 04103, Leipzig, Germany.
出版信息
Sci Rep. 2017 Jul 18;7(1):5664. doi: 10.1038/s41598-017-05912-x.
TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.
TGFβ1 是皮肤创伤后组织重塑诱导的关键调节因子。我们提出了一种基于纤维状 3D 胶原基质和嵌入 TGFβ1 释放微球的旁分泌递送 TGFβ1 的模型，用于真皮成纤维细胞的分化。我们发现，与全身递送相比，在低得多的剂量下，TGFβ1 依赖的方式可以实现向肌成纤维细胞的分化。这种效应归因于模仿旁分泌细胞信号的缓慢和持续的 TGFβ1 释放。
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