Calik Mustafa, Sen Dokumaci Dilek, Sarikaya Suna, Demir Mahmut, Isik Ilhan, Kazanasmaz Halil, Kaya Cemil, Kandemir Hasan
Department of Pediatric Neurology.
Department of Radiology.
Neuropsychiatr Dis Treat. 2017 Jun 26;13:1655-1660. doi: 10.2147/NDT.S135842. eCollection 2017.
Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of -acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all >0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells.
屏气发作是婴儿在哭闹发作后出现呼吸暂停和姿势肌张力改变的良性阵发性事件。本研究的目的是通过磁共振波谱（MRS）研究屏气发作儿童在无癫痫发作情况下脑代谢物值的病理情况。对18例屏气发作儿童和13例作为对照组的神经功能正常儿童进行了脑MRS检查。患者组和对照组之间的N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）和肌醇（mI）水平以及NAA/Cr、Cho/Cr和mI/Cr比值均无显著差异（均>0.05）。我们的研究表明，屏气发作患者不存在永久性神经元损伤。这一结果证实了先前的研究，即报道屏气发作患者不存在永久性神经元损伤。
