Pelczyńska Marta, Grzelak Teresa, Sperling Marcelina, Bogdański Paweł, Pupek-Musialik Danuta, Czyżewska Krystyna
Division of Biology of Civilization-Linked Diseases, Department of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Education and Obesity Treatment and Metabolic Disorders, Poznan University of Medical Sciences, Poznan, Poland.
Arch Med Sci. 2017 Jun;13(4):745-752. doi: 10.5114/aoms.2016.58594. Epub 2016 Mar 16.
Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other.
The studies were conducted on 79 people, including 52 with metabolic syndrome (MetS+) and 27 without it (MetS-). Biochemical measurements (lipid profile, glycemia, 25(OH)D, VDBP, albumin, calcium, parathyroid hormone) were performed, concentration of free and bioavailable vitamin D was mathematically calculated, and anthropometric and blood pressure measurements were taken.
The mean ± SD concentration of 25(OH)D among MetS+ individuals (41.90 ±13.12 nmol/l) was lower ( < 0.0001) than among the MetS- group (66.09 ±18.02 nmol/l). Differences between groups were observed in relation to medians/means of concentrations of free and bioavailable vitamin D ( < 0.0001) but not in the case of VDBP. In the entire study population, 25(OH)D correlated with all metabolic syndrome components, whereas its free and bioavailable fraction correlated with particular components of the syndrome. In the MetS+ group, VDBP concentration negatively correlated with body mass index ( = 0.037) and levels of diastolic pressure ( = 0.022). In the case of the MetS- group, the free fraction of vitamin D negatively correlated with triglyceridemia ( = 0.049).
The evaluation of various forms of vitamin D and VDBP in different population groups seems to have significant clinical value in evaluating the prevalence of metabolic disorders.
各种形式的维生素D及其代谢相关因子可能在代谢紊乱的病因发病机制中发挥作用。本文旨在确定一方面维生素D的羟基化形式（25(OH)D）的浓度、游离和生物可利用维生素D的比例以及维生素D结合蛋白（VDBP）水平，与另一方面代谢综合征各组分的患病率之间的关系。
对79人进行了研究，其中包括52名患有代谢综合征（MetS+）的人和27名未患代谢综合征（MetS-）的人。进行了生化测量（血脂谱、血糖、25(OH)D、VDBP、白蛋白、钙、甲状旁腺激素），通过数学计算得出游离和生物可利用维生素D的浓度，并进行了人体测量和血压测量。
MetS+个体中25(OH)D的平均±标准差浓度（41.90±13.12 nmol/l）低于（<0.0001）MetS-组（66.09±18.02 nmol/l）。在游离和生物可利用维生素D浓度的中位数/平均值方面观察到组间差异（<0.0001），但VDBP情况并非如此。在整个研究人群中，25(OH)D与所有代谢综合征组分相关，而其游离和生物可利用部分与该综合征的特定组分相关。在MetS+组中，VDBP浓度与体重指数呈负相关（=0.037），与舒张压水平呈负相关（=0.022）。在MetS-组中，维生素D的游离部分与高甘油三酯血症呈负相关（=0.049）。
在不同人群组中评估各种形式的维生素D和VDBP，对于评估代谢紊乱的患病率似乎具有重要的临床价值。
