六甲铵、阿方那特和美加明对小鼠二异丙基氟磷酸酯中毒的预防作用。

Prophylactic action of hexamethonium, trimethaphan, and mecamylamine against diisopropyl fluorophosphate poisoning in mice.

作者信息

Chiou G C, Chang W T, Aimoto T

出版信息

Fundam Appl Toxicol. 1986 Jan;6(1):35-43. doi: 10.1016/0272-0590(86)90261-7.

Abstract

Prophylactic Action of Hexamethonium, Trimethaphan, and Mecamylamine against Diisopropyl Fluorophosphate Poisoning in Mice. Chiou, G. C. Y., Chang, W. T. S., and Aimoto, T. (1986). Fund. Appl. Toxicol. 6, 35-43. Hexamethonium, trimethaphan, and mecamylamine are ganglionic blockers which can reduce acetylcholine (ACh) release presynaptically. All these agents are capable of protecting mice from diisopropyl fluorophosphate (DFP) intoxication by prolonging the latent period of death or by completely preventing death. Combinations of these agents with 2-pyridine aldoxime methochloride (2-PAM) (50 mg/kg) improved prophylactic action even further. These results indicate that reduction of ACh release presynaptically plus neutralization of organophosphates with 2-PAM could be an effective way to reduce mortality in patients exposed to organophosphorus poisons.

摘要

六甲铵、阿方那特和美加明对小鼠二异丙基氟磷酸酯中毒的预防作用。邱，G.C.Y.，张，W.T.S.，及相本，T.（1986年）。《基础与应用毒理学》6卷，第35 - 43页。六甲铵、阿方那特和美加明是神经节阻滞剂，可在突触前减少乙酰胆碱（ACh）释放。所有这些药物都能够通过延长死亡潜伏期或完全防止死亡来保护小鼠免受二异丙基氟磷酸酯（DFP）中毒。这些药物与氯解磷定（2 - PAM）（50毫克/千克）联合使用，预防作用甚至进一步增强。这些结果表明，突触前减少ACh释放并同时用2 - PAM中和有机磷酸酯可能是降低接触有机磷毒物患者死亡率的有效方法。