Department of Chemistry, Zhejiang University , Hangzhou 310027, China.
School of Chemical & Environmental Engineering, Wuyi University , Jiangmen 529020, China.
Org Lett. 2017 Aug 4;19(15):3950-3953. doi: 10.1021/acs.orglett.7b01529. Epub 2017 Jul 19.
The Ru-catalyzed meta-C-H benzylation of arenes bearing pyridyl, pyrimidyl, and pyrazolyl directing groups with toluene derivatives has been reported. Heptafluoroisopropyl iodide (CFI) was employed as both a mild oxidant and radical initiator. This reaction showed excellent site-selectivity and tolerated a wide range of functional groups, providing a new strategy for the synthesis of various diarylmethane moieties.
报道了 Ru 催化的带有吡啶基、嘧啶基和吡唑基导向基团的芳基与甲苯衍生物的间 C-H 苄基化反应。全氟异丙基碘（CFI）既可用作温和的氧化剂，也可用作自由基引发剂。该反应表现出优异的位点选择性，并能容忍广泛的官能团，为各种二芳基甲烷部分的合成提供了新策略。
