Luo Yu, Peng Xian, Duan Dingyu, Liu Chengcheng, Xu Xin, Zhou Xuedong
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
West China School of Stomatology, Sichuan University, Chengdu, China.
Curr Stem Cell Res Ther. 2018;13(2):144-150. doi: 10.2174/1574888X12666170718161740.
Periodontitis is a multifactorial infectious disease that affects a large population worldwide. Oral microorganisms and susceptible host have been proposed to be the prerequisite for the development of periodontitis. Recently, the involvement of epigenetic modifications in the development of periodontitis has been suggested.
This review aims to detail recent discoveries involving the epigenetic alterations in periodontitis, and discuss the possible epigenetic mechanisms contributing to the expression of periodontitis- related genes.
The expression of inflammatory cytokines during periodontitis is regulated at epigenetic level by mechanisms such as DNA methylation, histone modification and miRNAs. In addition, periodontal pathogens and their virulence factors could induce epigenetic alterations of periodontal tissues, and thus affect the progression and prognosis of periodontitis. The involvement of epigenetic modifications during periodontitis not only advances our knowledge on the pathogenesis of periodontitis, but may also lead to the identification of potential therapeutic targets of this oral disease.
牙周炎是一种影响全球大量人口的多因素感染性疾病。口腔微生物和易感宿主被认为是牙周炎发生发展的先决条件。最近，有研究表明表观遗传修饰参与了牙周炎的发生发展。
本综述旨在详细阐述牙周炎中表观遗传改变的最新发现，并探讨可能导致牙周炎相关基因表达的表观遗传机制。
牙周炎期间炎症细胞因子的表达在表观遗传水平上受DNA甲基化、组蛋白修饰和微小RNA等机制调控。此外，牙周病原体及其毒力因子可诱导牙周组织的表观遗传改变，从而影响牙周炎的进展和预后。表观遗传修饰在牙周炎中的参与不仅增进了我们对牙周炎发病机制的认识，还可能导致识别这种口腔疾病的潜在治疗靶点。
