Wang Yuan, Yuan Quan, Xie Liang
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Curr Stem Cell Res Ther. 2018;13(2):125-135. doi: 10.2174/1574888X12666170817141921.
Aging is characterized by time-dependent functional decline, which results in the reduced ability to cope with physiological challenges. The aging process can be affected by genetic factors, environment factors, epigenetic factors, and several stochastic factors. Epigenetic marker alteration during aging has been widely monitored and studied recently, since these epigenetic alterations are theoretically reversible.
In this review, we will elaborate on the connection between aging and histone modifications, mainly focusing on the major modification participated in aging and its underlying mechanism. We will also summarize the latest research progress of the potential and promising treatments or strategies that aim to reverse aging through the intervention of histone modifications.
Histone post-translational modifications play a crucial role in epigenetic alteration during aging, among which histone methylation and histone acetylation are emerging as two prominent modification methods. These modifications can serve as the therapeutic targets in the pursuit of rejuvenation.
衰老的特征是随时间推移的功能衰退，这导致应对生理挑战的能力下降。衰老过程会受到遗传因素、环境因素、表观遗传因素以及一些随机因素的影响。近年来，衰老过程中的表观遗传标记改变受到了广泛监测和研究，因为这些表观遗传改变在理论上是可逆的。
在本综述中，我们将详细阐述衰老与组蛋白修饰之间的联系，主要关注参与衰老的主要修饰及其潜在机制。我们还将总结旨在通过干预组蛋白修饰来逆转衰老的潜在且有前景的治疗方法或策略的最新研究进展。
组蛋白翻译后修饰在衰老过程中的表观遗传改变中起关键作用，其中组蛋白甲基化和组蛋白乙酰化正成为两种突出的修饰方式。这些修饰可作为追求年轻化的治疗靶点。
