Isanejad Masoud, LaCroix Andrea Z, Thomson Cynthia A, Tinker Lesley, Larson Joseph C, Qi Qibin, Qi Lihong, Cooper-DeHoff Rhonda M, Phillips Lawrence S, Prentice Ross L, Beasley Jeannette M
1Institute of Public Health and Clinical Nutrition,University of Eastern Finland,Kuopio,Finland.
2Department of Family Medicine and Public Health,University of California San Diego,San Diego, CA,USA.
Br J Nutr. 2017 Jun;117(11):1523-1530. doi: 10.1017/S0007114517001568.
Knowledge regarding association of dietary branched-chain amino acid (BCAA) and type 2 diabetes (T2D), and the contribution of BCAA from meat to the risk of T2D are scarce. We evaluated associations between dietary BCAA intake, meat intake, interaction between BCAA and meat intake and risk of T2D. Data analyses were performed for 74 155 participants aged 50-79 years at baseline from the Women's Health Initiative for up to 15 years of follow-up. We excluded from analysis participants with treated T2D, and factors potentially associated with T2D or missing covariate data. The BCAA and total meat intake was estimated from FFQ. Using Cox proportional hazards models, we assessed the relationship between BCAA intake, meat intake, and T2D, adjusting for confounders. A 20 % increment in total BCAA intake (g/d and %energy) was associated with a 7 % higher risk for T2D (hazard ratio (HR) 1·07; 95 % CI 1·05, 1·09). For total meat intake, a 20 % increment was associated with a 4 % higher risk of T2D (HR 1·04; 95 % CI 1·03, 1·05). The associations between BCAA intake and T2D were attenuated but remained significant after adjustment for total meat intake. These relations did not materially differ with or without adjustment for BMI. Our results suggest that dietary BCAA and meat intake are positively associated with T2D among postmenopausal women. The association of BCAA and diabetes risk was attenuated but remained positive after adjustment for meat intake suggesting that BCAA intake in part but not in full is contributing to the association of meat with T2D risk.
关于膳食支链氨基酸（BCAA）与2型糖尿病（T2D）之间的关联，以及肉类中BCAA对T2D风险的影响，目前所知甚少。我们评估了膳食BCAA摄入量、肉类摄入量、BCAA与肉类摄入量之间的相互作用以及T2D风险之间的关联。对来自女性健康倡议组织的74155名年龄在50 - 79岁的基线参与者进行了长达15年的随访数据分析。我们将接受治疗的T2D患者以及可能与T2D相关或缺失协变量数据的因素排除在分析之外。通过食物频率问卷（FFQ）估算BCAA和总肉类摄入量。使用Cox比例风险模型，我们评估了BCAA摄入量、肉类摄入量与T2D之间的关系，并对混杂因素进行了调整。BCAA总摄入量增加20%（克/天和能量百分比）与T2D风险升高7%相关（风险比（HR）1.07；95%置信区间1.05，1.09）。对于总肉类摄入量，增加20%与T2D风险升高4%相关（HR 1.04；95%置信区间1.03，1.05）。在调整总肉类摄入量后，BCAA摄入量与T2D之间的关联减弱，但仍然显著。无论是否调整体重指数（BMI），这些关系没有实质性差异。我们的结果表明，在绝经后女性中，膳食BCAA和肉类摄入量与T2D呈正相关。在调整肉类摄入量后，BCAA与糖尿病风险的关联减弱但仍然呈正相关，这表明BCAA摄入量部分但并非全部导致了肉类与T2D风险之间的关联。
