支链氨基酸的膳食摄入量与成年人 2 型糖尿病风险：哈尔滨饮食、营养与慢性非传染性疾病研究。

Dietary Intakes of Branched-Chained Amino Acid and Risk for Type 2 Diabetes in Adults: The Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases Study.

机构信息

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.

出版信息

Can J Diabetes. 2018 Oct;42(5):484-492.e7. doi: 10.1016/j.jcjd.2017.12.003. Epub 2017 Dec 12.

DOI:10.1016/j.jcjd.2017.12.003

PMID:29625864

Abstract

OBJECTIVES

To assess the association between branched-chain amino acid (BCAA) intakes and risk for type 2 diabetes.

METHODS

Dietary intakes were assessed in 1,804 people with type 2 diabetes and 7,020 controls with information on nutrient intakes, including BCAAs derived from Chinese food composition tables. Principal component analysis was used to identify dietary patterns (DPs) and multivariable-adjusted odds ratios (ORs) of type 2 diabetes, and 95% confidence intervals (CIs) by quartiles of BCAAs were estimated using logistic regression with 2-sided p<0.05.

RESULTS

Multivariable-adjusted ORs and 95% CI were 1.00, 1.297 (1.087 to 1.548), 1.380 (1.153 to 1.652) and 1.561 (1.291 to 1.888), p<0.0001, across energy-adjusted quartiles of total BCAA intakes. We identified 6 DPs: wheaten foods; vegetables, fruit and milk; beverages and snacks; potatoes, soybean and egg; meat; and fish. Multivariable-adjusted ORs and 95% CI across quartiles of total BCAA intakes for people with type 2 diabetes within the 4th quartile of DPs were 1.00, 1.337 (0.940 to 1.903); 1.579 (1.065 to 2.343); 2.412 (1.474 to 3.947); P=0.001 for vegetables, fruit and milk, 1.00, 1.309 (0.930 to 1.842), 1.328 (0.888 to 1.985), 2.044 (1.179 to 3.544); P=0.028 for meat and 1.00, 1.043 (0.720 to 1.509), 1.497 (0.969 to 2.312), 1.896 (1.067 to 3.367); P=0.017 for fish.

CONCLUSIONS

BCAA intakes and type 2 diabetes risk depend on the context of DPs, not exclusively on BCAA intake.

摘要

目的

评估支链氨基酸（BCAA）摄入与 2 型糖尿病风险之间的关联。

方法

纳入 1804 名 2 型糖尿病患者和 7020 名对照，通过中国食物成分表评估营养素摄入情况，包括支链氨基酸。采用主成分分析法识别膳食模式（DPs），采用多变量调整的比值比（OR）和 95%置信区间（CI）通过逻辑回归估计支链氨基酸摄入的四分位数（2 侧 p<0.05）。

结果

多变量调整后的 OR 和 95%CI 分别为 1.00、1.297（1.087 至 1.548）、1.380（1.153 至 1.652）和 1.561（1.291 至 1.888），p<0.0001，支链氨基酸总摄入量的能量调整四分位数跨越。我们确定了 6 个 DPs：小麦食品；蔬菜、水果和牛奶；饮料和零食；土豆、大豆和鸡蛋；肉；和鱼。在 DP 第 4 四分位数的 2 型糖尿病患者中，支链氨基酸总摄入量的四分位数跨越时的多变量调整 OR 和 95%CI 为 1.00、1.337（0.940 至 1.903）；1.579（1.065 至 2.343）；2.412（1.474 至 3.947）；P=0.001 用于蔬菜、水果和牛奶；1.00、1.309（0.930 至 1.842）、1.328（0.888 至 1.985）、2.044（1.179 至 3.544）；P=0.028 用于肉；1.00、1.043（0.720 至 1.509）、1.497（0.969 至 2.312）、1.896（1.067 至 3.367）；P=0.017 用于鱼。