Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak- ro, Gwanak-gu, Seoul, 08826, Korea.
Research Institute of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Nutr J. 2023 Jul 11;22(1):34. doi: 10.1186/s12937-023-00861-w.
The potential role of dietary branched-chain amino acids (BCAA) in metabolic health, including cardiovascular disease and diabetes, is evolving, and it is yet to be understood if dietary BCAA intakes are associated with plasma lipid profiles or dyslipidaemia. This study tested the association of dietary BCAA intakes with plasma lipid profiles and dyslipidaemia among Filipino women in Korea.
Energy-adjusted dietary BCAA intakes (isoleucine, leucine, valine, and total BCAA) and fasting blood profiles of triglycerides (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were determined in a sample of 423 women enrolled in the Filipino Women's Diet and Health Study (FiLWHEL). The generalized linear model was applied to estimate least-square (LS) means and 95% confidence intervals (CIs) and compare plasma TG, TC, HDL-C, and LDL-C across tertile distribution of energy-adjusted dietary BCAA intakes at P < 0.05.
Mean of energy-adjusted dietary total BCAA intake was 8.3 ± 3.9 g/d. Average plasma lipid profiles were 88.5 ± 47.4 mg/dl for TG, 179.7 ± 34.5 mg/dl for TC, 58.0 ± 13.7 mg/dl for HDL-C, and 104.0 ± 30.5 mg/dl for LDL-C. LS means, and 95% CIs across tertiles of energy-adjusted total BCAA intakes were 89.9 mg/dl, 88.8 mg/dl and 85.8 mg/dl (P-trend = 0.45) for TG, 179.1 mg/dl, 183.6 mg/dl and 176.5 mg/dl (P-trend = 0.48) for TC, 57.5 mg/dl, 59.6 mg/dl and 57.1 mg/dl (P-trend = 0.75) for HDL-C and 103.6 mg/dl, 106.2 mg/dl and 102.3 mg/dl (P-trend = 0.68) for LDL-C. Furthermore, the multivariable-adjusted prevalence ratios and 95% confidence intervals for dyslipidaemia across increasing tertile distribution of energy-adjusted total BCAA intake were; 1.00, 0.67 (0.40, 1.13) and 0.45 (0.16, 1.27; P-trend = 0.03) for the first, second and third tertile, respectively.
Higher dietary intakes of BCAA presented a statistically significant inverse trend with the prevalence of dyslipidaemia among Filipino women in this study and testing these associations in longitudinal studies may be necessary to confirm these findings.
膳食支链氨基酸（BCAA）在代谢健康方面的潜在作用，包括心血管疾病和糖尿病，正在不断发展，人们还不清楚膳食 BCAA 摄入量是否与血浆脂质谱或血脂异常有关。本研究旨在检验菲律宾女性在韩国的膳食 BCAA 摄入量与血浆脂质谱和血脂异常之间的关系。
在菲律宾女性饮食与健康研究（FiLWHEL）中，对 423 名女性进行了能量校正后的膳食 BCAA 摄入量（异亮氨酸、亮氨酸、缬氨酸和总 BCAA）和空腹血脂谱（甘油三酯 [TG]、总胆固醇 [TC]、高密度脂蛋白胆固醇 [HDL-C]和低密度脂蛋白胆固醇 [LDL-C]）的测定。采用广义线性模型估计最小二乘（LS）均值和 95%置信区间（CI），并在 P < 0.05 时比较能量校正后的膳食总 BCAA 摄入量三分位分布的血浆 TG、TC、HDL-C 和 LDL-C。
能量校正后的膳食总 BCAA 摄入量的平均值为 8.3 ± 3.9 g/d。平均血浆脂质谱为：TG 88.5 ± 47.4 mg/dl，TC 179.7 ± 34.5 mg/dl，HDL-C 58.0 ± 13.7 mg/dl，LDL-C 104.0 ± 30.5 mg/dl。能量校正后总 BCAA 摄入量三分位的 LS 均值和 95%CI 分别为：TG 为 89.9 mg/dl、88.8 mg/dl 和 85.8 mg/dl（P-trend = 0.45），TC 为 179.1 mg/dl、183.6 mg/dl 和 176.5 mg/dl（P-trend = 0.48），HDL-C 为 57.5 mg/dl、59.6 mg/dl 和 57.1 mg/dl（P-trend = 0.75），LDL-C 为 103.6 mg/dl、106.2 mg/dl 和 102.3 mg/dl（P-trend = 0.68）。此外，能量校正后的总 BCAA 摄入量三分位分布的血脂异常多变量调整比值比和 95%CI 分别为：1.00、0.67（0.40，1.13）和 0.45（0.16，1.27；P-trend = 0.03）。
较高的膳食 BCAA 摄入量与本研究中菲律宾女性血脂异常的患病率呈统计学上显著的负相关，在纵向研究中检验这些关联可能有必要以证实这些发现。
