Stålhandske T, Kalland T
Immunopharmacology. 1986 Apr;11(2):87-92. doi: 10.1016/0162-3109(86)90028-7.
Treatment of Sprague-Dawley rats with the compound LS 2616, a quinoline-3-carboxamide, enhanced the delayed-type hypersensitivity response (DTH) to recall antigens as judged by the specific accumulation of inflammatory cells after challenge with Bordetella pertussis in the pleural space. LS 2616 was effective when given both before sensitization and at the time of secondary antigen challenge. The effect of LS 2616 on DTH was dose-dependent. LS 2616 was highly effective in enhancing DTH in rats with suppressed cell-mediated immunity after treatment with anti-thymocyte globulin or prednisolone, indicating its possible value in the immunosuppressed state.
用喹啉 - 3 - 甲酰胺化合物LS 2616处理斯普拉格 - 道利大鼠，增强了对回忆抗原的迟发型超敏反应（DTH），这是通过在胸膜腔中用百日咳博德特氏菌攻击后炎症细胞的特异性积累来判断的。LS 2616在致敏前和二次抗原攻击时给予均有效。LS 2616对DTH的作用呈剂量依赖性。在用抗胸腺细胞球蛋白或泼尼松龙治疗后细胞介导免疫受到抑制的大鼠中，LS 2616在增强DTH方面非常有效，表明其在免疫抑制状态下可能具有价值。
