Ben-Josef Avital Mazar, Chen Jerry, Wileyto Paul, Doucette Abigail, Bekelman Justin, Christodouleas John, Deville Curtiland, Vapiwala Neha
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1036-1044. doi: 10.1016/j.ijrobp.2017.03.043. Epub 2017 Mar 31.
A randomized phase II study was performed to measure the potential therapeutic effects of yoga on fatigue, erectile dysfunction, urinary incontinence, and overall quality of life (QOL) in prostate cancer (PCa) patients undergoing external beam radiation therapy (RT).
The participants were randomized to yoga and no-yoga cohorts (1:1). Twice-weekly yoga interventions were offered throughout the 6- to 9-week courses of RT. Comparisons of standardized assessments were performed between the 2 cohorts for the primary endpoint of fatigue and the secondary endpoints of erectile dysfunction, urinary incontinence, and QOL before, during, and after RT.
From October 2014 to January 2016, 68 eligible PCa patients underwent informed consent and agreed to participate in the study. Of the 68 patients, 18 withdrew early, mostly because of treatment schedule-related time constraints, resulting in 22 and 28 patients in the yoga and no-yoga groups, respectively. Throughout treatment, those in the yoga arm reported less fatigue than those in the control arm, with global fatigue, effect of fatigue, and severity of fatigue subscales showing statistically significant interactions (P<.0001). The sexual health scores (International Index of Erectile Function Questionnaire) also displayed a statistically significant interaction (P=.0333). The International Prostate Symptom Score revealed a statistically significant effect of time (P<.0001) but no significant effect of treatment (P=.1022). The QOL measures had mixed results, with yoga having a significant time by treatment effect on the emotional, physical, and social scores but not on functional scores.
A structured yoga intervention of twice-weekly classes during a course of RT was associated with a significant reduction in pre-existing and RT-related fatigue and urinary and sexual dysfunction in PCa patients.
开展一项随机II期研究，以评估瑜伽对接受体外放射治疗（RT）的前列腺癌（PCa）患者的疲劳、勃起功能障碍、尿失禁及总体生活质量（QOL）的潜在治疗效果。
参与者被随机分为瑜伽组和非瑜伽组（1:1）。在为期6至9周的放疗过程中，每周提供两次瑜伽干预。对两组在放疗前、放疗期间及放疗后的主要终点疲劳以及次要终点勃起功能障碍、尿失禁和生活质量进行标准化评估比较。
2014年10月至2016年1月，68例符合条件的PCa患者签署知情同意书并同意参与研究。68例患者中，18例提前退出，主要原因是与治疗计划相关的时间限制，最终瑜伽组和非瑜伽组分别有22例和28例患者。在整个治疗过程中，瑜伽组患者报告的疲劳程度低于对照组，全球疲劳、疲劳影响及疲劳严重程度分量表显示出具有统计学意义的交互作用（P<0.0001）。性健康评分（国际勃起功能指数问卷）也显示出具有统计学意义的交互作用（P=0.0333）。国际前列腺症状评分显示出具有统计学意义的时间效应（P<0.0001），但无显著的治疗效应（P=0.1022）。生活质量测量结果不一，瑜伽对情绪、身体和社会评分有显著的时间与治疗交互效应，但对功能评分无此效应。
在放疗过程中每周进行两次的结构化瑜伽干预与PCa患者先前存在的及放疗相关的疲劳、泌尿和性功能障碍的显著减轻相关。
