胰腺腺鳞癌（PASC）的基因组特征

Genomic signatures of pancreatic adenosquamous carcinoma (PASC).

作者信息

Fang Yuan, Su Zhe, Xie Jing, Xue Ruidong, Ma Qi, Li Yanmeng, Zhao Yifan, Song Zeshi, Lu Xiongxiong, Li Hongwei, Peng Chenghong, Bai Fan, Shen Baiyong

机构信息

Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.

Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.

出版信息

J Pathol. 2017 Oct;243(2):155-159. doi: 10.1002/path.4943. Epub 2017 Sep 5.

DOI:10.1002/path.4943

PMID:28722109

Abstract

In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

摘要

在胰腺癌中，胰腺腺鳞癌（PASC）是指在同一肿瘤中同时包含导管腺癌和鳞癌成分，约占胰腺癌总发病率的4%。迄今为止，这种混合性肿瘤的基因组特征仍不清楚。我们分析了17例胰腺腺鳞癌和34例胰腺导管腺癌（PDAC）的基因组，结果显示与胰腺导管腺癌相比，胰腺腺鳞癌携带高度富集的TP53突变和3p缺失。我们还发现，胰腺腺鳞癌的腺瘤样成分和鳞癌成分具有相当的基因组改变，这表明这两种细胞成分是由相同的祖代癌细胞发展而来。我们的研究更新了基因组学知识，有助于理解胰腺混合性癌症。版权所有© 2017英国及爱尔兰病理学会。由约翰·威利父子有限公司出版。