胰腺腺鳞癌中的肉瘤样成分：7例临床病理系列研究
Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases.
作者信息
Taniwaki Shinichi, Hisaka Toru, Sakai Hisamune, Goto Yuichi, Nomura Yoriko, Kawahara Ryuichi, Ishikawa Hiroto, Yasunaga Masafumi, Naito Yoshiki, Akiba Jun, Yano Hirohisa, Tanaka Hiroyuki, Akagi Yoshito, Okuda Koji
机构信息
Department of Surgery, Faculty of Medicine, Kurume University, Fukuoka, Japan.
Department of Surgery, Faculty of Medicine, Kurume University, Fukuoka, Japan
出版信息
Anticancer Res. 2019 Aug;39(8):4575-4580. doi: 10.21873/anticanres.13636.
BACKGROUND/AIM: The aim of this study was to examine the clinicopathological features of pancreatic adenosquamous carcinoma (PASC).
PATIENTS AND METHODS
Our study included seven patients who underwent resection of PASC.
RESULTS
PASC is characterized by large tumors and strong infiltration into the major blood vessels and other organs, forcing many patients to undergo extended resections. In addition, all patients experienced liver metastasis recurrence following surgery, with a very poor prognosis. Histopathologically, a poorly differentiated sarcomatous component existed in all patients in addition to an adenocarcinoma component and squamous carcinoma component. Although P40 staining for the sarcomatous component was positive along with squamous carcinoma, E-cadherin expression disappeared while vimentin was expressed. It has been suggested that it is highly likely that these sarcomatous components are derived from squamous carcinoma and have an impact on prognosis.
CONCLUSION
The sarcomatous component may be related to the biological malignancy of PASC.
背景/目的：本研究旨在探讨胰腺腺鳞癌（PASC）的临床病理特征。
患者与方法
我们的研究纳入了7例行PASC切除术的患者。
结果
PASC的特点是肿瘤较大，对主要血管和其他器官有较强浸润，致使许多患者需接受扩大切除术。此外，所有患者术后均出现肝转移复发，预后极差。组织病理学上，除腺癌成分和鳞癌成分外，所有患者均存在低分化肉瘤成分。尽管肉瘤成分与鳞癌一样P40染色呈阳性，但E-钙黏蛋白表达消失而波形蛋白表达。提示这些肉瘤成分很可能来源于鳞癌并影响预后。
结论
肉瘤成分可能与PASC的生物学恶性程度有关。
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