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Nrf2 作为一种通过对抗氧化应激预防年龄相关性和糖尿病性白内障的靶点。

Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress.

机构信息

Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.

Department of Neurosurgery, The People's Hospital of Jilin Province, Jilin, China.

出版信息

Aging Cell. 2017 Oct;16(5):934-942. doi: 10.1111/acel.12645. Epub 2017 Jul 19.

DOI:10.1111/acel.12645
PMID:28722304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5595676/
Abstract

Cataract is one of the most important causes of blindness worldwide, with age-related cataract being the most common one. Agents preventing cataract formation are urgently required. Substantial evidences point out aggravated oxidative stress as a vital factor for cataract formation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) system is considered as one of the main cellular defense mechanisms against oxidative stresses. This review discusses the role of Nrf2 pathway in the prevention of cataracts and highlights that Nrf2 suppressors may augment oxidative stress of the lens, and Nrf2 inducers may decrease the oxidative stress and prevent the cataract formation. Thus, Nrf2 may serve as a promising therapeutic target for cataract treatment.

摘要

白内障是全球范围内导致失明的主要原因之一，其中年龄相关性白内障最为常见。因此，我们迫切需要寻找能够预防白内障形成的药物。大量证据表明，氧化应激的加剧是白内障形成的一个重要因素。核因子（红细胞衍生 2）样 2（Nrf2）/Kelch 样红细胞衍生蛋白与 CNC 同源（ECH）相关蛋白 1（Keap1）系统被认为是对抗氧化应激的主要细胞防御机制之一。本综述讨论了 Nrf2 通路在白内障预防中的作用，并强调 Nrf2 抑制剂可能会增加晶状体的氧化应激，而 Nrf2 诱导剂则可能降低氧化应激并预防白内障的形成。因此，Nrf2 可能成为白内障治疗的有前途的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22bd/5595676/45203e59fda2/ACEL-16-934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22bd/5595676/c181f3841876/ACEL-16-934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22bd/5595676/45203e59fda2/ACEL-16-934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22bd/5595676/c181f3841876/ACEL-16-934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22bd/5595676/45203e59fda2/ACEL-16-934-g002.jpg

相似文献

[1]
Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress.

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[2]
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[2]
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[3]
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Int J Ophthalmol. 2024-10-18

[4]
Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.

Neurotherapeutics. 2024-9

[5]
Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies.

Biomolecules. 2024-8-25

[6]
Research progress on the correlation between cataract occurrence and nutrition.

Front Nutr. 2024-7-1

[7]
Utilization of Nitrogen-Doped Graphene Quantum Dots to Neutralize ROS and Modulate Intracellular Antioxidant Pathways to Improve Dry Eye Disease Therapy.

Int J Nanomedicine. 2024

[8]
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.

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[9]
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[10]
Oxidative stress in the eye and its role in the pathophysiology of ocular diseases.

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本文引用的文献

[1]
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Sci Rep. 2017-4-11

[2]
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Aging Cell. 2017-6

[3]
Curcumin, A Potential Therapeutic Candidate for Anterior Segment Eye Diseases: A Review.

Front Pharmacol. 2017-2-14

[4]
Cataracts.

Lancet. 2017-2-25

[5]
Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases.

Oxid Med Cell Longev. 2016

[6]
Activation of apoptosis signalling pathways by reactive oxygen species.

Biochim Biophys Acta. 2016-12

[7]
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Aging Cell. 2016-10

[8]
Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease.

J Neurosci Res. 2016-10

[9]
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

J Gerontol A Biol Sci Med Sci. 2016-7

[10]
Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer.

Mol Pharm. 2016-6-6

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