Liu Xiu-Fen, Hao Ji-Long, Xie Tian, Mukhtar Nour Jama, Zhang Wiley, Malik Tayyab Hamid, Lu Cheng-Wei, Zhou Dan-Dan
Department of Ophthalmology, The First Hospital of Jilin University Changchun, China.
Department of Neurosurgery, The People's Hospital of Jilin Province Changchun, China.
Front Pharmacol. 2017 Feb 14;8:66. doi: 10.3389/fphar.2017.00066. eCollection 2017.
Curcumin, the major curcuminoid of the turmeric, has been extensively used in many countries since ancient time for preventing and/or treating a multitude of diseases. This review is to illustrate the researches on the properties of curcumin and its potential therapeutic efficacy in major anterior segment eye diseases. The bio-medical potential of curcumin is restricted because of its low solubility and digestive bioavailability. This review will discuss promising research in improving curcumin bioavailability through structural modification. and research made progress in studying the beneficial effects of curcumin on major anterior segment eye diseases, including anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis, anterior uveitis; anti-proliferation and pro-apoptosis effects in pterygium; anti-oxidative stress, anti-osmotic stress, anti-lipid peroxidation, pro-apoptosis, regulating calcium homeostasis, sequestrating free radicals, protein modification and degradation effects in cataracts; neuroprotective effects in glaucoma. Curcumin exhibited to be a potent therapeutic candidate for treating those anterior segment eye diseases.
姜黄素是姜黄中的主要姜黄素类化合物，自古以来就在许多国家被广泛用于预防和/或治疗多种疾病。本综述旨在阐述姜黄素的特性及其在主要眼前节眼病中的潜在治疗效果的研究。姜黄素的生物医学潜力因其低溶解度和消化生物利用度而受到限制。本综述将讨论通过结构修饰提高姜黄素生物利用度的有前景的研究。并且在研究姜黄素对主要眼前节眼病的有益作用方面取得了进展，包括在角膜疾病中的抗血管生成作用；在干眼病、结膜炎、前葡萄膜炎中的抗炎或抗过敏作用；在翼状胬肉中的抗增殖和促凋亡作用；在白内障中的抗氧化应激、抗渗透应激、抗脂质过氧化、促凋亡、调节钙稳态、清除自由基、蛋白质修饰和降解作用；在青光眼中的神经保护作用。姜黄素显示出是治疗那些眼前节眼病的有力候选药物。
