Kaminski Tim, Gunnarsson Anders, Geschwindner Stefan
Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca , Pepparedsleden 1, S-43183 Mölndal, Sweden.
ACS Sens. 2017 Jan 27;2(1):10-15. doi: 10.1021/acssensors.6b00735. Epub 2016 Dec 23.
Optical biosensors entered target-based small-molecule drug discovery more than two decades ago and have since transformed into a value-adding component in the decision-making process. Here, we briefly highlight the major application areas of optical biosensors and focus on desirable profiles of such platforms in order to ensure their effective use in small molecule drug discovery. Furthermore, we will emphasize current technology-based constraints and discuss experimental strategies to address these limitations as well as provide a view of necessary technology improvements for next generation platforms.
二十多年前，光学生物传感器就进入了基于靶点的小分子药物发现领域，此后已转变为决策过程中的一个增值组件。在此，我们简要介绍光学生物传感器的主要应用领域，并关注此类平台的理想特性，以确保它们在小分子药物发现中得到有效应用。此外，我们将强调当前基于技术的限制，讨论解决这些限制的实验策略，并展望下一代平台所需的技术改进。
