乳铁蛋白对子孢子的杀伤作用。
Killing of sporozoites by Lactoferrin.
作者信息
Paredes Jose Luis, Sparks Hayley, White A Clinton, Martinez-Traverso Griselle, Ochoa Theresa, Castellanos-González Alejandro
机构信息
Universidad Peruana Cayetano Heredia, Lima, Peru.
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
出版信息
Am J Trop Med Hyg. 2017 Sep;97(3):774-776. doi: 10.4269/ajtmh.16-0804. Epub 2017 Jul 19.
Intestinal infection caused by is a major contributor to diarrhea morbidity and mortality in young children around the world. Current treatments for children suffering from cryptosporidiosis are suboptimal. Lactoferrin is a glycoprotein found in breast milk. It has showed bacteriostatic and antimicrobial activity in the intestine. However, the effects of lactoferrin on the intestinal parasite have not been reported. In this study, we investigated the anticryptosporidial activity of human lactoferrin on different stages of . Physiologic concentrations of lactoferrin killed sporozoites, but had no significant effect on oocysts viability or parasite intracellular development. Since sporozoites are essential for the infection process, our data reinforce the importance of breastfeeding and point to the potential of lactoferrin as a novel therapeutic agent for cryptosporidiosis.
由[未提及的病原体]引起的肠道感染是全球幼儿腹泻发病和死亡的主要原因。目前针对患隐孢子虫病儿童的治疗方法并不理想。乳铁蛋白是一种存在于母乳中的糖蛋白。它在肠道中已显示出抑菌和抗菌活性。然而，乳铁蛋白对肠道寄生虫[未提及的寄生虫名称]的作用尚未见报道。在本研究中，我们调查了人乳铁蛋白对[未提及的寄生虫名称]不同阶段的抗隐孢子虫活性。生理浓度的乳铁蛋白可杀死[未提及的寄生虫名称]子孢子，但对卵囊活力或寄生虫细胞内发育没有显著影响。由于子孢子是感染过程所必需的，我们的数据强化了母乳喂养的重要性，并指出乳铁蛋白作为隐孢子虫病新型治疗剂的潜力。
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