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A Rapid Epidemiological Tool to Measure the Burden of Norovirus Infection and Disease in Resource-Limited Settings.一种用于在资源有限环境中衡量诺如病毒感染和疾病负担的快速流行病学工具。
Open Forum Infect Dis. 2017 Mar 17;4(2):ofx049. doi: 10.1093/ofid/ofx049. eCollection 2017 Spring.
2
Norovirus in Latin America: Systematic Review and Meta-analysis.拉丁美洲的诺如病毒：系统评价与荟萃分析。
Pediatr Infect Dis J. 2017 Feb;36(2):127-134. doi: 10.1097/INF.0000000000001369.
3
Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study.运用定量分子诊断方法确定儿童腹泻病因：全球儿童急性腹泻病监测研究病例对照研究的重新分析
Lancet. 2016 Sep 24;388(10051):1291-301. doi: 10.1016/S0140-6736(16)31529-X.
4
The Center for Human Development in Guatemala: An Innovative Model for Global Population Health.危地马拉人类发展中心：全球人口健康的创新模式。
Adv Pediatr. 2016 Aug;63(1):357-87. doi: 10.1016/j.yapd.2016.04.001. Epub 2016 Jun 3.
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Human norovirus transmission and evolution in a changing world.人类诺如病毒在不断变化的世界中的传播和进化。
Nat Rev Microbiol. 2016 Jul;14(7):421-33. doi: 10.1038/nrmicro.2016.48. Epub 2016 May 23.
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The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control.诺如病毒的全球负担广泛且多样：预防与控制的前景
PLoS Med. 2016 Apr 26;13(4):e1001999. doi: 10.1371/journal.pmed.1001999. eCollection 2016 Apr.
7
Estimating the Risk of Domestic Water Source Contamination Following Precipitation Events.估算降水事件后家庭水源污染的风险。
Am J Trop Med Hyg. 2016 Jun 1;94(6):1403-6. doi: 10.4269/ajtmh.15-0600. Epub 2016 Apr 25.
8
Status of vaccine research and development for norovirus.诺如病毒疫苗研发现状。
Vaccine. 2016 Jun 3;34(26):2895-2899. doi: 10.1016/j.vaccine.2016.03.077. Epub 2016 Mar 29.
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Norovirus Infection and Acquired Immunity in 8 Countries: Results From the MAL-ED Study.8个国家的诺如病毒感染与获得性免疫：MAL-ED研究结果
Clin Infect Dis. 2016 May 15;62(10):1210-7. doi: 10.1093/cid/ciw072. Epub 2016 Mar 24.
10
Use of rapid needs assessment as a tool to identify vaccination delays in Guatemala and Peru.将快速需求评估作为识别危地马拉和秘鲁疫苗接种延误情况的工具加以运用。
Vaccine. 2016 Mar 29;34(14):1719-25. doi: 10.1016/j.vaccine.2016.01.060. Epub 2016 Feb 19.

快速主动抽样调查作为评估危地马拉农村儿童急性胃肠炎和诺如病毒感染相关因素的工具

Rapid Active Sampling Surveys as a Tool to Evaluate Factors Associated with Acute Gastroenteritis and Norovirus Infection among Children in Rural Guatemala.

作者信息

Olson Daniel, Lamb Molly M, Lopez Maria R, Paniagua-Avila Maria A, Zacarias Alma, Samayoa-Reyes Gabriela, Cordon-Rosales Celia, Asturias Edwin J

机构信息

Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.

Center for Global Health, Colorado School of Public Health, Aurora, Colorado.

出版信息

Am J Trop Med Hyg. 2017 Sep;97(3):944-948. doi: 10.4269/ajtmh.16-1003. Epub 2017 Jul 19.

DOI:10.4269/ajtmh.16-1003
PMID:28722580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5590593/
Abstract

We examined burden and factors associated with norovirus (NoV) acute gastroenteritis (AGE) among children in rural Guatemala. Children age 6 weeks to 17 years were enrolled into three AGE surveillance groups, using two-stage cluster sampling: a prospective participatory syndromic surveillance (PSS) cohort and two cross-sectional rapid active sampling (RAS) surveys, conducted from April 2015 to February 2016. Epidemiologic and NoV testing data were used to identify factors associated with NoV infection, AGE, and NoV+ AGE. The three cross-sectional surveys (PSS enrollment visit, RAS Survey 1, and RAS Survey 2) enrolled 1,239 children, who reported 134 (11%) AGE cases, with 20% of AGE and 11% of non-AGE samples positive for NoV. Adjusted analyses identified several modifiable factors associated with AGE and NoV infection. The cross-sectional RAS surveys were practical and cost-effective in identifying population-level risk factors for AGE and NoV, supporting their use as a tool to direct limited public health resources toward high-risk populations.

摘要

我们调查了危地马拉农村地区儿童中与诺如病毒（NoV）急性胃肠炎（AGE）相关的负担及因素。采用两阶段整群抽样法，将6周龄至17岁的儿童纳入三个AGE监测组：一个前瞻性参与性症状监测（PSS）队列以及两项横断面快速主动抽样（RAS）调查，研究于2015年4月至2016年2月进行。利用流行病学和NoV检测数据来确定与NoV感染、AGE以及NoV+AGE相关的因素。三项横断面调查（PSS入组访视、RAS调查1和RAS调查2）共纳入了1239名儿童，这些儿童报告了134例（11%）AGE病例，其中20%的AGE样本和11%的非AGE样本NoV检测呈阳性。校正分析确定了几个与AGE和NoV感染相关的可改变因素。横断面RAS调查在确定AGE和NoV的人群水平风险因素方面既实用又具有成本效益，支持将其用作一种工具，以便将有限的公共卫生资源导向高危人群。