Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.
Dasman Diabetes Institute, Kuwait City, Kuwait.
Diabetes Metab Res Rev. 2017 Nov;33(8). doi: 10.1002/dmrr.2919. Epub 2017 Aug 30.
Diabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has shown that ANGPTL8 was expressed in liver, white adipose, and brown adipose tissues. ANGPTL8 regulates the activity of lipoprotein lipase, which is a key enzyme in lipoprotein lipolysis pathway through its direct interaction with ANGPTL3. It has been also reported that it regulates the replication of β-cells in response to insulin resistance. As a result, many recent studies have focused on the association of ANGPTL8 with diabetes and obesity as well as its association with various metabolic markers in order to better understand its physiological role in glucose homeostasis and lipid metabolism. In this review, we will highlight some of the key clinical findings, mainly from human studies, that investigated the role of ANGPTL8 in metabolic diseases such as diabetes, obesity, and the metabolic syndrome.
糖尿病是一种全球范围内的主要疾病，其发病率正在达到流行水平。它的患病率增加以及与心血管疾病、肾病和视网膜病变等多种并发症的高发病率相关，使其成为一个重要的研究疾病。ANGPTL8 是一种新发现的激素，与 2 型糖尿病的胰岛素抵抗和脂质代谢这两个重要功能过程有关。初步研究表明，ANGPTL8 在肝脏、白色脂肪组织和棕色脂肪组织中表达。ANGPTL8 通过与 ANGPTL3 的直接相互作用调节脂蛋白脂肪酶的活性，脂蛋白脂肪酶是脂蛋白脂肪分解途径中的关键酶。据报道，它还调节β细胞对胰岛素抵抗的复制。因此，许多最近的研究集中在 ANGPTL8 与糖尿病和肥胖的相关性及其与各种代谢标志物的相关性，以更好地了解其在葡萄糖稳态和脂质代谢中的生理作用。在这篇综述中，我们将重点介绍一些关键的临床发现，主要来自人类研究，这些研究探讨了 ANGPTL8 在代谢性疾病（如糖尿病、肥胖和代谢综合征）中的作用。
