Pohorecky L A
J Pharm Pharmacol. 1986 Apr;38(4):283-7. doi: 10.1111/j.2042-7158.1986.tb04567.x.
The effect of peripherally administered drugs that modify monoaminergic function, on ethanol (2.0 g kg-1, intragastrically)-induced changes in urine output has been examined in rats. The alpha-noradrenoceptor agonist, clonidine (0.05-0.15 mg kg-1) produced marked urine output and potentiated slightly the diuretic effect of ethanol. The alpha-noradrenoceptor antagonist, phentolamine (1-5 mg kg-1) dose-dependently decreased ethanol-induced diuresis. p-Chloroamphetamine (0.8-2.0 mg kg-1) produced significant diuresis and potentiated the diuresis produced by ethanol. Methysergide (1.25, 2.5 mg kg-1), a 5-hydroxytryptamine receptor antagonist, had no effect on urine output while it depressed the ethanol-induced increase in urine output. Apomorphine (0.8, 1.5 mg kg-1), a dopamine receptor agonist, did not modify urine output in either control or ethanol-treated animals, while the dopamine receptor antagonist, pimozide (0.75-3.0 mg kg-1), dose-dependently decreased ethanol-induced diuresis, but had no effect on urine output in control animals. Since our previous research indicates that the intraventricular administration of drugs that alter dopaminergic and 5-HT function does not alter ethanol-induced diuresis, the interaction of these types of agents with ethanol-induced diuresis in the present study suggests that the interaction was mediated peripherally.
已在大鼠中研究了外周给予的改变单胺能功能的药物对乙醇（2.0 g/kg，灌胃）诱导的尿量变化的影响。α-去甲肾上腺素能受体激动剂可乐定（0.05 - 0.15 mg/kg）可显著增加尿量，并轻微增强乙醇的利尿作用。α-去甲肾上腺素能受体拮抗剂酚妥拉明（1 - 5 mg/kg）剂量依赖性地降低乙醇诱导的利尿作用。对氯苯丙胺（0.8 - 2.0 mg/kg）可产生显著利尿作用，并增强乙醇产生的利尿作用。5-羟色胺受体拮抗剂麦角新碱（1.25、2.5 mg/kg）对尿量无影响，但可抑制乙醇诱导的尿量增加。多巴胺受体激动剂阿扑吗啡（0.8、1.5 mg/kg）在对照动物或乙醇处理的动物中均未改变尿量，而多巴胺受体拮抗剂匹莫齐特（0.75 - 3.0 mg/kg）剂量依赖性地降低乙醇诱导的利尿作用，但对对照动物的尿量无影响。由于我们之前的研究表明，脑室内给予改变多巴胺能和5-羟色胺功能的药物不会改变乙醇诱导的利尿作用，本研究中这些类型的药物与乙醇诱导的利尿作用之间的相互作用表明这种相互作用是由外周介导的。
