Pohorecky L A
J Pharm Pharmacol. 1985 Apr;37(4):271-3. doi: 10.1111/j.2042-7158.1985.tb05060.x.
Ethanol has been shown to produce a biphasic dose-dependent effect on urine output in rats. Experiments were carried out to examine factors which may influence ethanol diuresis. Immobilization stress (30 min) decreased and ethanol (2.5 g kg-1) increased urine output of intragastrically hydrated rats. In stressed rats, ethanol had a more pronounced diuretic effect compared with home cage control rats. This increased sensitivity to ethanol disappeared when rats were immobilized daily for four days, indicating development of tolerance. The diuretic action of ethanol was not influenced by adrenalectomy.
乙醇已被证明对大鼠尿量产生双相剂量依赖性效应。进行实验以研究可能影响乙醇利尿作用的因素。束缚应激（30分钟）使经胃内补水的大鼠尿量减少，而乙醇（2.5克/千克）则使其尿量增加。在应激大鼠中，与笼养对照大鼠相比，乙醇的利尿作用更为明显。当大鼠每天束缚四天时，这种对乙醇的敏感性增加消失，表明产生了耐受性。乙醇的利尿作用不受肾上腺切除术的影响。
