Kirtane Kedar, Lee Stephanie J
Division of Medical Oncology, University of Washington, Seattle, WA; and.
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA.
Blood. 2017 Oct 12;130(15):1699-1705. doi: 10.1182/blood-2017-04-778225. Epub 2017 Jul 19.
Racial and ethnic disparities in patients with solid malignancies have been well documented. Less is known about these disparities in patients with hematologic malignancies. With the advent of novel chemotherapeutics and targeted molecular, cellular, and immunologic therapies, it is important to identify differences in care that may lead to disparate outcomes. This review provides a critical appraisal of the empirical research on racial and ethnic disparities in incidence, survival, and outcomes in patients with hematologic malignancies. The review focuses on patients with acute myeloid leukemia, acute lymphocytic leukemia, multiple myeloma, non-Hodgkin lymphoma, Hodgkin lymphoma, myeloproliferative neoplasms, and myelodysplastic syndrome. The review discusses possible causes of racial and ethnic disparities and also considers future directions for studies to help decrease disparities.
实体恶性肿瘤患者中的种族和族裔差异已有充分记录。而血液系统恶性肿瘤患者中的这些差异则鲜为人知。随着新型化疗药物以及靶向分子、细胞和免疫疗法的出现,识别可能导致不同结果的治疗差异至关重要。本综述对血液系统恶性肿瘤患者在发病率、生存率和预后方面的种族和族裔差异的实证研究进行了批判性评估。该综述聚焦于急性髓系白血病、急性淋巴细胞白血病、多发性骨髓瘤、非霍奇金淋巴瘤、霍奇金淋巴瘤、骨髓增殖性肿瘤和骨髓增生异常综合征患者。综述讨论了种族和族裔差异的可能原因,并考虑了有助于减少差异的未来研究方向。