Katzka David A
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Am J Gastroenterol. 2017 Jul;112(7):1072-1073. doi: 10.1038/ajg.2017.136.
Eosinophilic esophagitis (EoE) is a food allergen disorder driven by antigen recognition in the gastrointestinal tract. The study by Warners et al., strongly supports the esophageal epithelium as the area of disturbed permeability and primary target for initiation of the TH2-induced allergic pathway. In contrast, small bowel assessment reveals a lack of clear change in aspects of permeability compared to controls. It is not clear, however, if the available testing used for this purpose accurately assesses the mechanisms by which antigen recognition may occur in this organ. As a result, the role of the small bowel in EoE remains unclear.
嗜酸性粒细胞性食管炎（EoE）是一种由胃肠道抗原识别驱动的食物过敏症。Warners等人的研究有力地支持了食管上皮是通透性受干扰的区域以及TH2诱导的过敏途径起始的主要靶点。相比之下，小肠评估显示与对照组相比，通透性方面缺乏明显变化。然而，尚不清楚用于此目的的现有检测是否准确评估了该器官中抗原识别可能发生的机制。因此，小肠在EoE中的作用仍不清楚。
