感染犬心丝虫的犬血清对称二甲基精氨酸的评估。
Evaluation of serum symmetric dimethylarginine in dogs with heartworm infection.
作者信息
Choi Bom-Sul, Moon Hyeongsun, Suh Sang-Il, Hyun Changbaig
机构信息
Department of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea (Choi, Suh, Hyun); Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Moon).
出版信息
Can J Vet Res. 2017 Jul;81(3):228-230.
This study evaluated the circulating levels of serum symmetric dimethylarginine (SDMA) in 12 dogs with different severities of heartworm disease (HWD) and assessed the biochemical renal markers (blood urea nitrogen, creatinine). Dogs were classified into 2 groups based on the severity of clinical signs. Group A - asymptomatic to mild clinical signs, group B - moderate to severe clinical signs. The serum SDMA levels were higher in dogs in group B. Although the serum SDMA levels in dogs in group A were also higher than those of the control dogs, the difference was not statistically significant. There was a good correlation between renal markers and severity of clinical signs. This study demonstrated that the glomerular filtration rate was significantly decreased in dogs in group A; therefore, earlier detection of renal impairment is required for successful management of dogs with HWD.
本研究评估了12只患有不同严重程度心丝虫病（HWD）犬的血清对称二甲基精氨酸（SDMA）循环水平，并评估了肾脏生化指标（血尿素氮、肌酐）。根据临床症状的严重程度将犬分为2组。A组——无症状至轻度临床症状，B组——中度至重度临床症状。B组犬的血清SDMA水平较高。虽然A组犬的血清SDMA水平也高于对照犬，但差异无统计学意义。肾脏指标与临床症状严重程度之间存在良好的相关性。本研究表明，A组犬的肾小球滤过率显著降低；因此，对于成功管理患有HWD的犬，需要更早地检测出肾功能损害。
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