全身淋巴照射对慢性进行性多发性硬化症的影响。

Effect of total lymphoid irradiation in chronic progressive multiple sclerosis.

作者信息

Cook S D, Devereux C, Troiano R, Hafstein M P, Zito G, Hernandez E, Lavenhar M, Vidaver R, Dowling P C

出版信息

Lancet. 1986 Jun 21;1(8495):1405-9. doi: 10.1016/s0140-6736(86)91554-0.

Abstract

Total lymphoid irradiation (TLI; 1980 cGy) or sham irradiation was given to 40 patients with chronic progressive multiple sclerosis (MS) in a prospective, randomised, double-blind study. During mean follow-up of 21 months, MS patients treated with TLI had less functional decline than sham-irradiated MS patients (p less than 0.01). A significant relation was noted between absolute blood lymphocyte counts in the first year after TLI and subsequent course, patients with higher lymphocyte counts generally having a worse prognosis (p less than 0.01). TLI was well tolerated and associated with only mild short-term, and to date, long-term side-effects.

摘要

在一项前瞻性、随机、双盲研究中，对40例慢性进行性多发性硬化症（MS）患者进行了全身淋巴照射（TLI；1980 cGy）或假照射。在平均21个月的随访期间，接受TLI治疗的MS患者功能下降程度低于接受假照射的MS患者（p<0.01）。TLI后第一年的绝对血淋巴细胞计数与随后病程之间存在显著相关性，淋巴细胞计数较高的患者预后通常较差（p<0.01）。TLI耐受性良好，仅伴有轻微的短期副作用，迄今为止也未发现长期副作用。