慢性进行性多发性硬化症患者接受全身淋巴照射后T细胞亚群与疾病进展
T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.
作者信息
Troiano R, Devereux C, Oleske J, Denny T, Hafstein M, Zito G, Rohowski-Kochan C, Dowling P C, Cook S D
机构信息
Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):980-3. doi: 10.1136/jnnp.51.7.980.
T lymphocyte subset percentages were determined in 16 total lymphoid irradiation (TLI) treated and 18 sham treated control patients with chronic progressive multiple sclerosis. During the first year after treatment, the ratio of T helper/inducer to T suppressor/cytotoxic cells (Th/Ts ratio) was significantly higher in sham treated multiple sclerosis patients who worsened clinically compared with TLI treated and sham treated multiple sclerosis patients who remained clinically stable. TLI caused a fall in the percentage of T helper cells in treated patients, while the percentage of T suppressor cells remained stable during the first year after treatment. In contrast, the percentage of T suppressor cells fell in sham treated multiple sclerosis patients who worsened clinically.
对16例接受全身淋巴照射（TLI）治疗的慢性进行性多发性硬化症患者和18例接受假治疗的对照患者测定了T淋巴细胞亚群百分比。在治疗后的治疗后的第一年，与接受TLI治疗且临床稳定的假治疗多发性硬化症患者相比，临床症状恶化的假治疗多发性硬化症患者中辅助性/诱导性T细胞与抑制性/细胞毒性T细胞的比例（Th/Ts比例）显著更高。TLI导致治疗患者中辅助性T细胞百分比下降，而在治疗后的第一年抑制性T细胞百分比保持稳定。相比之下，临床症状恶化的假治疗多发性硬化症患者中抑制性T细胞百分比下降。
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