侵袭性肺接合菌病后成功进行单倍体相合干细胞移植并预防性给予两性霉素B脂质体。
Successful haploidentical stem cell transplantation with prophylactic administration of liposomal amphotericin B after invasive pulmonary zygomycosis.
作者信息
Ochi Testuro, Katayama Yuta, Okatani Takeshi, Imanaka Ryota, Kyo Kohei, Itagaki Mitsuhiro, Katsutani Shinya, Iwato Koji, Asaoku Hideki
机构信息
Department of Hematology and Rheumatology, Tohoku University Hospital, 1-1, Seiryomachi, Aoba-ku Sendai-shi, Miyagi 980-0872, Japan.
Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivors' Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan.
出版信息
Med Mycol Case Rep. 2017 Jul 4;18:1-4. doi: 10.1016/j.mmcr.2017.07.002. eCollection 2017 Dec.
A 54-year-old woman with acute myeloid leukemia (AML) achieved complete remission by induction chemotherapy, but developed zygomycosis after consolidation therapy. As zygomycosis could not be cured by liposomal amphotericin B and micafungin, left lower lobectomy was performed. As AML relapsed 7 months after onset, she received haploidentical stem cell transplantation under administration of liposomal amphotericin B. Despite experiencing severe acute graft-versus-host disease, she remains alive with no relapse of either zygomycosis or AML.
一名54岁的急性髓系白血病（AML）女性患者通过诱导化疗实现了完全缓解，但在巩固治疗后发生了接合菌病。由于脂质体两性霉素B和米卡芬净无法治愈接合菌病，遂进行了左下叶切除术。由于AML在发病7个月后复发，她在接受脂质体两性霉素B治疗的同时接受了单倍体相合干细胞移植。尽管经历了严重的急性移植物抗宿主病，但她仍然存活，接合菌病和AML均未复发。
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